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Spn42Dc Serpin 42Dc [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35600, updated on 9-Dec-2024

Summary

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Official Symbol
Spn42Dcprovided by FlyBase
Official Full Name
Serpin 42Dcprovided by FlyBase
Primary source
FLYBASE:FBgn0033113
Locus tag
Dmel_CG9455
See related
AllianceGenome:FB:FBgn0033113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9455; Dmel\CG9455
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Spn42Dc in Genome Data Viewer
Location:
42D6-42D6; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6880995..6883407)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2768500..2770912)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44169 Neighboring gene Serpin 42Da Neighboring gene Serpin 42Db Neighboring gene Serpin 42Dd Neighboring gene Serpin 42De Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  2. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
  3. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
  4. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774
  5. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin 42Dc
Names
CG9455-PA
CG9455-PB
Spn42Dc-PA
Spn42Dc-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6880995..6883407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259225.2 → NP_001246154.1  serpin 42Dc, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6R4
    Conserved Domains (1) summary
    cd00172
    Location:7 → 377
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_136401.5 → NP_610245.2  serpin 42Dc, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610245.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6R4
    Related
    FBpp0085495
    Conserved Domains (1) summary
    cd00172
    Location:7 → 377
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z6R4 A1Z6R4
Q8T3Z2 Q8T3Z2

Gene LinkOut

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