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Epac - Exchange protein directly activated by cAMP

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in regulation of Rap protein signal transduction. Predicted to be active in plasma membrane. Is expressed in adult head; midline glial cell; and midline primordium. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa