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Cyp6w1 Cytochrome P450 6w1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35543, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp6w1provided by FlyBase
Official Full Name
Cytochrome P450 6w1provided by FlyBase
Primary source
FLYBASE:FBgn0033065
Locus tag
Dmel_CG8345
See related
AllianceGenome:FB:FBgn0033065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6w1; AntP450; CG8345; Cyp6W1; CYP6w1; CYP6W1; Dmel\CG8345
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be involved in insecticide catabolic process and response to DDT. Is expressed in embryonic Malpighian tubule segment; embryonic/larval fat body; embryonic/larval midgut; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp6w1 in Genome Data Viewer
Location:
42A12-42A12; 2-55 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6173684..6176195)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2061189..2063700)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Lysine-CTT 1-5 Neighboring gene transfer RNA:Arginine-ACG 1-4 Neighboring gene transfer RNA:Arginine-ACG 1-5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into DDT Resistance from the Drosophila melanogaster Genetic Reference Panel. Schmidt JM, et al. Genetics, 2017 Nov. PMID 28935691, Free PMC Article
  2. Xenobiotic response in Drosophila melanogaster: sex dependence of P450 and GST gene induction. Le Goff G, et al. Insect Biochem Mol Biol, 2006 Aug. PMID 16876710
  3. The biology of insecticidal activity and resistance. Perry T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21426939
  4. Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster. Wan H, et al. Pest Manag Sci, 2014 Jul. PMID 24038867
  5. Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models. Bargiela A, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31754023, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in insecticide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to DDT IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 6w1
Names
CG8345-PA
CG8345-PB
Cyp6w1-PA
Cyp6w1-PB
cytochrome P450
NP_001286145.1
NP_610206.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6173684..6176195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299216.1 → NP_001286145.1  cytochrome P450 6w1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9L1
    UniProtKB/TrEMBL
    A0A0B4LEU2
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 501
    p450; Cytochrome P450

  2. NM_136362.3 → NP_610206.1  cytochrome P450 6w1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9L1
    UniProtKB/TrEMBL
    A0A0B4LEU2
    Related
    FBpp0085332
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 501
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEU2 A0A0B4LEU2
Q9V9L1.1 Q9V9L1

Gene LinkOut

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