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IL1R1 interleukin 1 receptor type 1 [ Homo sapiens (human) ]

Gene ID: 3554, updated on 27-Nov-2024

Summary

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Official Symbol
IL1R1provided by HGNC
Official Full Name
interleukin 1 receptor type 1provided by HGNC
Primary source
HGNC:HGNC:5993
See related
Ensembl:ENSG00000115594 MIM:147810; AllianceGenome:HGNC:5993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P80; IL1R; CRMO3; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha
Summary
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 42.4), placenta (RPKM 40.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See IL1R1 in Genome Data Viewer
Location:
2q11.2-q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102070390..102179874)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102528685..102638160)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102686850..102796334)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor type 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102637443-102637636 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene interleukin 1 receptor like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients]. Zhong LJ, et al. Zhonghua Kou Qiang Yi Xue Za Zhi, 2003 Sep. PMID 14680589
  2. Polymorphisms in exons 1B and 1C of the type I interleukin-1 receptor gene in patients with endometriosis. D'Amora P, et al. Am J Reprod Immunol, 2006 Sep. PMID 16911713
  3. Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout. Lo SF, et al. Clin Exp Rheumatol, 2005 Jan-Feb. PMID 15789892
  4. Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Chittezhath M, et al. Immunity, 2014 Nov 20. PMID 25453823
  5. IL-1R1 is expressed on both Helios(+) and Helios(-) FoxP3(+) CD4(+) T cells in the rheumatic joint. Müller M, et al. Clin Exp Immunol, 2015 Oct. PMID 26076982, Free PMC Article

See all (322) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons.
    Title: Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons.
  2. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4[+] T cell responses following COVID-19 mRNA vaccination.
    Title: IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4(+) T cell responses following COVID-19 mRNA vaccination.
  3. ANGPTL3 negatively regulates IL-1beta-induced NF-kappaB activation by inhibiting the IL1R1-associated signaling complex assembly.
    Title: ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly.
  4. A paracrine circuit of IL-1beta/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
    Title: A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
  5. The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.
    Title: The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.
  6. IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study.
    Title: IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study.
  7. Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children.
    Title: Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children.
  8. Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia.
    Title: Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia.
  9. IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease.
    Title: IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease.
  10. Expression of obesity- and type-2 diabetes-associated genes in omental adipose tissue of individuals with obesity.
    Title: Expression of obesity- and type-2 diabetes-associated genes in omental adipose tissue of individuals with obesity.
Submit: New GeneRIF Correction See all GeneRIFs (143)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Chronic recurrent multifocal osteomyelitis 3
MedGen: CN376807 OMIM: 259680 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide association study to identify genetic determinants of severe asthma.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of IL-1RA in uninfected mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T-helper 1 cell cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neutrophil extravasation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interleukin-1 IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor type 1
Names
CD121 antigen-like family member A
interleukin 1 receptor alpha, type I
interleukin-1 receptor alpha
interleukin-1 receptor type I
NP_000868.1
NP_001275635.1
NP_001307907.1
NP_001307909.1
NP_001307910.1
NP_001307911.1
NP_001307912.1
NP_001307913.1
NP_001307914.1
NP_001307915.1
XP_005263987.1
XP_005263991.1
XP_011509417.1
XP_011509418.1
XP_011509420.1
XP_047300132.1
XP_047300133.1
XP_047300134.1
XP_047300135.1
XP_047300136.1
XP_047300137.1
XP_047300138.1
XP_047300139.1
XP_054197786.1
XP_054197787.1
XP_054197788.1
XP_054197789.1
XP_054197790.1
XP_054197791.1
XP_054197792.1
XP_054197793.1
XP_054197794.1
XP_054197795.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000877.4 → NP_000868.1  interleukin-1 receptor type 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, AL548240, BE144272, BQ021163, HY092388, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Related
    ENSP00000386380.1, ENST00000410023.6
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  2. NM_001288706.2 → NP_001275635.1  interleukin-1 receptor type 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AK314433, AL548240, BE144272, BQ021163, DA861783, M27492
    Consensus CDS
    CCDS74547.1
    UniProtKB/TrEMBL
    B8ZZW4, Q6NWP5
    Related
    ENSP00000386776.1, ENST00000409929.5
    Conserved Domains (5) summary
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3 → 320
    PHA02785; IL-beta-binding protein; Provisional
    smart00255
    Location:380 → 509
    TIR; Toll - interleukin 1 - resistance
    cl11960
    Location:226 → 327
    Ig; Immunoglobulin domain

  3. NM_001320978.2 → NP_001307907.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007271, AK314433, CB240976, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  4. NM_001320980.2 → NP_001307909.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, AU136426, CB240976, DB226934, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  5. NM_001320981.2 → NP_001307910.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, BX472731, CB240976, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  6. NM_001320982.2 → NP_001307911.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, CB240976, DA333942, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  7. NM_001320983.1 → NP_001307912.1  interleukin-1 receptor type 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013913, CD014140, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:240 → 396
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:13 → 18
    Ig; Ig strand C [structural motif]
    cd20932
    Location:82 → 185
    Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:1 → 75
    Ig; Immunoglobulin domain

  8. NM_001320984.1 → NP_001307913.1  interleukin-1 receptor type 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013912, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (3) summary
    smart00255
    Location:201 → 357
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:51 → 145
    IG_like; Immunoglobulin like
    cl11960
    Location:1 → 36
    Ig; Immunoglobulin domain

  9. NM_001320985.1 → NP_001307914.1  interleukin-1 receptor type 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013913, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (2) summary
    smart00255
    Location:149 → 305
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:1 → 93
    IG_like; Immunoglobulin like

  10. NM_001320986.2 → NP_001307915.1  interleukin-1 receptor type 1 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AU136426, CA421991, DB226934
    UniProtKB/TrEMBL
    B9A040
    Related
    ENSP00000386555.1, ENST00000409589.5
    Conserved Domains (3) summary
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:43 → 103
    IG_like; Immunoglobulin like
    cl11960
    Location:128 → 162
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    102070390..102179874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511115.3 → XP_011509417.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509417.1

    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  2. XM_011511116.2 → XP_011509418.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509418.1

    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  3. XM_005263930.4 → XP_005263987.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263987.1

    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  4. XM_047444179.1 → XP_047300135.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  5. XM_047444176.1 → XP_047300132.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  6. XM_047444177.1 → XP_047300133.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  7. XM_047444180.1 → XP_047300136.1  interleukin-1 receptor type 1 isoform X2

  8. XM_005263934.5 → XP_005263991.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263991.1

    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  9. XM_047444178.1 → XP_047300134.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  10. XM_047444181.1 → XP_047300137.1  interleukin-1 receptor type 1 isoform X2

  11. XM_047444183.1 → XP_047300139.1  interleukin-1 receptor type 1 isoform X2

  12. XM_011511118.3 → XP_011509420.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509420.1

    UniProtKB/Swiss-Prot
    P14778, Q587I7
    UniProtKB/TrEMBL
    Q6NWP5
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234 → 328
    IG; Immunoglobulin
    cd05756
    Location:24 → 113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  13. XM_047444182.1 → XP_047300138.1  interleukin-1 receptor type 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102528685..102638160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341813.1 → XP_054197788.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  2. XM_054341812.1 → XP_054197787.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  3. XM_054341811.1 → XP_054197786.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  4. XM_054341817.1 → XP_054197792.1  interleukin-1 receptor type 1 isoform X2

  5. XM_054341814.1 → XP_054197789.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  6. XM_054341816.1 → XP_054197791.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  7. XM_054341818.1 → XP_054197793.1  interleukin-1 receptor type 1 isoform X2

  8. XM_054341820.1 → XP_054197795.1  interleukin-1 receptor type 1 isoform X2

  9. XM_054341815.1 → XP_054197790.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778, Q587I7

  10. XM_054341819.1 → XP_054197794.1  interleukin-1 receptor type 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14778.1 GenPept UniProtKB/Swiss-Prot:P14778

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