Tbce Tubulin-binding cofactor E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tbceprovided by FlyBase
Official Full Name: Tubulin-binding cofactor Eprovided by FlyBase
Primary source: FLYBASE:FBgn0033055
Locus tag: Dmel_CG7861
See related: AllianceGenome:FB:FBgn0033055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7861; Dmel\CG7861; dTBCE; tbce; TBCE
Summary: Predicted to enable alpha-tubulin binding activity. Involved in microtubule polymerization; neuromuscular synaptic transmission; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm. Is expressed in several structures, including embryonic/larval epidermis; larval central nervous system; larval muscle system; larval ventral nerve cord; and spermatid axoneme. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 1; hypoparathyroidism; and hypoparathyroidism-retardation-dysmorphism syndrome. Orthologous to human TBCE (tubulin folding cofactor E). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42A8-42A8; 2-55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6042532..6044964)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1930037..1932469)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulin-specific chaperone E (TBCE) is required for the normal development and function of neuromuscular synapses and that it promotes microtubule formation
Title: Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-chaperonin tubulin folding pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tubulin-binding cofactor E

Names: CG7861-PB; CG7861-PC; Tbce-PB; Tbce-PC; tubulin-specific chaperone E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6042532..6044964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136353.2 → NP_610197.2 Tubulin-binding cofactor E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610197.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6J4, A1Z6J5, Q8MT85

Conserved Domains (3) summary

smart01052
Location:14 → 79

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:158 → 183

LRR_RI; leucine-rich repeat [structural motif]

cl26161
Location:148 → 268

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_206025.2 → NP_995747.1 Tubulin-binding cofactor E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995747.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6J4, A1Z6J5, Q8MT85

Conserved Domains (3) summary

smart01052
Location:14 → 79

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:158 → 183

LRR_RI; leucine-rich repeat [structural motif]

cl26161
Location:148 → 268

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...