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hrm hermes [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35499, updated on 4-Jan-2025

Summary

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Official Symbol
hrmprovided by FlyBase
Official Full Name
hermesprovided by FlyBase
Primary source
FLYBASE:FBgn0033028
Locus tag
Dmel_CG11665
See related
AllianceGenome:FB:FBgn0033028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11665; Dmel\CG11665; Hermes
Summary
Enables pyruvate secondary active transmembrane transporter activity. Involved in plasma membrane pyruvate transport. Located in plasma membrane. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See hrm in Genome Data Viewer
Location:
41F6-41F6; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5640915..5652815, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1528420..1540320, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Fission, mitochondrial 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45472 Neighboring gene CCR4-NOT transcription complex subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
  2. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article
  3. dMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor growth. Rebelo AR, et al. Cell Mol Life Sci, 2023 Jan 6. PMID 36609617, Free PMC Article
  4. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
  5. dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain. Perlegos AE, et al. Sci Rep, 2023 Dec 28. PMID 38155219, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5644537-5644489 mobile_element_type = transposon:INE-1{}5059
  • Loc: c5645255-5645046 mobile_element_type = transposon:INE-1{}5061
  • Loc: c5646356-5646156 mobile_element_type = transposon:INE-1{}5062
  • Loc: c5649611-5649558 mobile_element_type = transposon:INE-1{}5068
  • Loc: c5649719-5649632 mobile_element_type = transposon:INE-1{}5072
  • Loc: c5650444-5650112 mobile_element_type = transposon:HB{}5693
  • Loc: c5650571-5650446 mobile_element_type = transposon:INE-1{}3428

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate secondary active transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in plasma membrane lactate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane pyruvate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hermes
Names
CG11665-PA
CG11665-PB
hrm-PA
hrm-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5640915..5652815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299212.1 → NP_001286141.1  hermes, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286141.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWI7
    Conserved Domains (2) summary
    cd06174
    Location:59 → 234
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:49 → 653
    2A0113; monocarboxylate transporter 1

  2. NM_136330.2 → NP_610174.1  hermes, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWI7
    Related
    FBpp0085408
    Conserved Domains (2) summary
    cd06174
    Location:59 → 234
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:49 → 653
    2A0113; monocarboxylate transporter 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWI7 Q7JWI7

Gene LinkOut

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