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sxc super sex combs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35486, updated on 9-Dec-2024

Summary

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Official Symbol
sxcprovided by FlyBase
Official Full Name
super sex combsprovided by FlyBase
Primary source
FLYBASE:FBgn0261403
Locus tag
Dmel_CG10392
See related
AllianceGenome:FB:FBgn0261403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH04245; CG10392; Dmel\CG10392; DmOGT; dO-GnT; l(2)02637; l(2)NC130; ogt; Ogt; OGT; P1201; Sxc; SXC; sxc/Ogt
Summary
Enables protein O-acetylglucosaminyltransferase activity. Involved in several processes, including locomotor rhythm; positive regulation of fibroblast growth factor receptor signaling pathway; and protein O-linked glycosylation. Is expressed in adult head and organism. Used to study non-syndromic X-linked intellectual disability 106. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sxc in Genome Data Viewer
Location:
41E4-41E5; 2-55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5307288..5329555)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1194793..1217060)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR41443 Neighboring gene d4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development. Mariappa D, et al. Biochem J, 2015 Sep 1. PMID 26348912, Free PMC Article
  2. A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins. Liu TW, et al. ACS Cent Sci, 2019 Apr 24. PMID 31041386, Free PMC Article
  3. A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila. Ingham PW. Cell, 1984 Jul. PMID 6430566
  4. The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Jínek M, et al. Nat Struct Mol Biol, 2004 Oct. PMID 15361863
  5. Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p. Li Q, et al. Mol Neurobiol, 2024 Jan. PMID 37597108

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 5309114-5311497 mobile_element_type = transposon:1360{}644
  • Loc: 5311605-5311882 mobile_element_type = transposon:FB{}3670
  • Loc: 5313143-5315274 mobile_element_type = transposon:Rt1b{}3595
  • Loc: 5315424-5315718 mobile_element_type = transposon:I{}3122
  • Loc: 5319716-5319832 mobile_element_type = transposon:Transpac{}3603
  • Loc: 5320913-5321012 mobile_element_type = transposon:INE-1{}3176
  • Loc: 5321034-5321102 mobile_element_type = transposon:INE-1{}3178
  • Loc: 5322624-5322718 mobile_element_type = transposon:INE-1{}3179
  • Loc: 5323463-5323518 mobile_element_type = transposon:ninja-Dsim-like{}3776
  • Loc: 5323910-5324185 mobile_element_type = transposon:INE-1{}3180
  • Loc: 5324219-5324324 mobile_element_type = transposon:INE-1{}3182
  • Loc: 5328095-5328420 mobile_element_type = transposon:INE-1{}3195

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
super sex combs
Names
CG10392-PA
CG10392-PB
CG10392-PC
O-GlcNAc transferase
O-glycosyltransferase
O-linked N-acetylglucosamine transferase
lethal (2) NC130
sxc-PA
sxc-PB
sxc-PC
NP_523620.1
NP_724406.1
NP_724407.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5307288..5329555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165427.2 → NP_724407.1  super sex combs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJA9, Q9Y148
    Related
    FBpp0085422
    Conserved Domains (8) summary
    COG0457
    Location:233 → 490
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:255 → 282
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:118 → 151
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:356 → 385
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:118 → 183
    TPR_11; TPR repeat
    pfam13424
    Location:182 → 252
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:310 → 342
    TPR_17; Tetratricopeptide repeat
    pfam13844
    Location:584 → 1044
    Glyco_transf_41; Glycosyl transferase family 41

  2. NM_165426.2 → NP_724406.1  super sex combs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJA9, Q9Y148
    Related
    FBpp0085421
    Conserved Domains (8) summary
    COG0457
    Location:233 → 490
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:255 → 282
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:118 → 151
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:356 → 385
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:118 → 183
    TPR_11; TPR repeat
    pfam13424
    Location:182 → 252
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:310 → 342
    TPR_17; Tetratricopeptide repeat
    pfam13844
    Location:584 → 1044
    Glyco_transf_41; Glycosyl transferase family 41

  3. NM_078896.3 → NP_523620.1  super sex combs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523620.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJA9, Q9Y148
    Related
    FBpp0085420
    Conserved Domains (8) summary
    COG0457
    Location:233 → 490
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:255 → 282
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:118 → 151
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:356 → 385
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:118 → 183
    TPR_11; TPR repeat
    pfam13424
    Location:182 → 252
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:310 → 342
    TPR_17; Tetratricopeptide repeat
    pfam13844
    Location:584 → 1044
    Glyco_transf_41; Glycosyl transferase family 41
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KJA9 Q7KJA9
Q95RP9 Q95RP9
Q9Y148 Q9Y148

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