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gus gustavus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35478, updated on 4-Jan-2025

Summary

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Official Symbol
gusprovided by FlyBase
Official Full Name
gustavusprovided by FlyBase
Primary source
FLYBASE:FBgn0026238
Locus tag
Dmel_CG2944
See related
AllianceGenome:FB:FBgn0026238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A11; CG2944; CG2946; Dmel\CG2944; dmSSB4; Gus; GUS; i25
Summary
Involved in several processes, including dorsal appendage formation; germ cell migration; and regionalization. Located in several cellular components, including cell cortex; perinuclear region of cytoplasm; and pole plasm. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in germarium; nurse cell; oocyte; organism; and ovary. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) and SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gus in Genome Data Viewer
Location:
41D3-41D3; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5116990..5128321, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1004495..1015826, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43256 Neighboring gene Atf6 Neighboring gene Nipped-A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. Kugler JM, et al. G3 (Bethesda), 2013 Sep 4. PMID 23893743, Free PMC Article
  2. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Kugler JM, et al. Mol Cell Biol, 2010 Apr. PMID 20123973, Free PMC Article
  3. Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis. Kugler JM, et al. PLoS One, 2010 Feb 4. PMID 20140218, Free PMC Article
  4. Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen. Anne J, et al. Development, 2005 May. PMID 15800004
  5. VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Styhler S, et al. Dev Cell, 2002 Dec. PMID 12479811

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5118216-5117941 mobile_element_type = transposon:INE-1{}2086
  • Loc: c5119554-5119303 mobile_element_type = transposon:INE-1{}2087
  • Loc: c5124998-5124882 mobile_element_type = transposon:INE-1{}2917
  • Loc: c5126720-5125750 mobile_element_type = transposon:1360{}2914
  • Loc: c5127918-5126750 mobile_element_type = transposon:INE-1{}2912

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in oocyte anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pole plasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gustavus
Names
CG2944-PG
CG2944-PH
CG2944-PI
CG2944-PJ
CG2944-PK
CG2944-PL
CG2944-PM
gus-PG
gus-PH
gus-PI
gus-PJ
gus-PK
gus-PL
gus-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5116990..5128321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165419.3 → NP_724399.2  gustavus, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724399.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  2. NM_001259211.2 → NP_001246140.1  gustavus, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  3. NM_165421.3 → NP_724401.2  gustavus, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724401.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  4. NM_165422.3 → NP_724402.2  gustavus, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724402.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  5. NM_165418.3 → NP_724398.2  gustavus, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724398.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  6. NM_165420.3 → NP_724400.2  gustavus, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724400.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

  7. NM_136314.4 → NP_610158.3  gustavus, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610158.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1
    UniProtKB/TrEMBL
    A0A0B4K6X3
    Conserved Domains (2) summary
    cd03718
    Location:234 → 276
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:56 → 229
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6X3 A0A0B4K6X3
A1Z6E0.2 A1Z6E0

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