dimm dimmed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dimmprovided by FlyBase
Official Full Name: dimmedprovided by FlyBase
Primary source: FLYBASE:FBgn0023091
Locus tag: Dmel_CG8667
See related: AllianceGenome:FB:FBgn0023091
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHa16; c929; CG8667; dim; Dimm; DIMM; Dmel\CG8667; Mistr
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in neuroendocrine cell differentiation; positive regulation of secretion; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; gland; neurosecretory neurons; peptidergic neurons; and peritracheal cell. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 39D1-39D1; 2-54 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21331756..21342155)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21331756..21342155)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using single cell mass spectrometry, this study analyzed 10 types of dimmed neurons from the brain/gnathal ganglion. These cells included neuroendocrine cells with projection into the retrocerebral complex but also a number of large interneurons.
Title: Neuropeptide Mapping of Dimmed Cells of Adult Drosophila Brain.
DIMM prescribes the scale of secretory activity in neuroendocrine neurons, by a systematic control of both proximal and distal points in the regulated secretory pathway.
Title: Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED.
We also show that dInR expression in neuroendocrine cells can be altered by up or down-regulation of Dimm.
Title: Insulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in Drosophila.
G protein-coupled receptor mist and its ligand fog have roles in regulating epithelial morphogenesis
Title: Regulation of epithelial morphogenesis by the G protein-coupled receptor mist and its ligand fog.
Loss of SSDP, a key regulatory component of CHIP/LDB transcription complexes, alters transcription of a large group of genes.
Title: Transcriptional regulation by CHIP/LDB complexes.
Nonpeptidergic neurons normally fail to accumulate ectopic neuropeptides. They will do so when they are also forced to express ectopic DIMM.
Title: Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM.
DIMMED has a special role in the development and maintenance of neurosecretory cell fate in Drosophila as a dedicated pro-secretory factor.
Title: Peptidergic neurosecretory cells in insects: organization and control by the bHLH protein DIMMED.
DIMM is a master regulator of a peptidergic cell fate in Drosophila and provides a detailed transcriptional mechanism of DIMM action on a defined target gene
Title: The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme.
The roles of crc and dimmed genes on the expression of diverse hormones in D. melanogaster and reported.
Title: Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 21334487-21334781 mobile_element_type = transposon:INE-1{}4090
Loc: 21336291-21337335 mobile_element_type = transposon:G5A{}4174

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dimmed

Names: CG8667-PA; CG8667-PB; dimm-PA; dimm-PB; mist 1-related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

21331756..21342155

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273745.1 → NP_001260674.1 dimmed, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260674.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQA1, Q0IGR9, Q9VID2

UniProtKB/TrEMBL

M9PDD7

Conserved Domains (1) summary

cd00083
Location:154 → 208

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_078887.3 → NP_523611.1 dimmed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523611.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQA1, Q0IGR9, Q9VID2

UniProtKB/TrEMBL

M9PDD7

Related

FBpp0081042

Conserved Domains (1) summary

cd00083
Location:154 → 208

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...