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Noc2 Nucleolar complex protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35386, updated on 4-Jan-2025

Summary

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Official Symbol
Noc2provided by FlyBase
Official Full Name
Nucleolar complex protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0032925
Locus tag
Dmel_CG9246
See related
AllianceGenome:FB:FBgn0032925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9246; Dmel\CG9246; NOC2?
Summary
Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Noc2 in Genome Data Viewer
Location:
39A7-39A7; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21163641..21166090)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21163641..21166090)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3 Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition. Destefanis F, et al. J Cell Sci, 2022 Dec 1. PMID 36314272, Free PMC Article
  2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
  3. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Abramov YA, et al. Genetics, 2016 Jan. PMID 26500261, Free PMC Article
  4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc1p-Noc2p complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of Noc2p-Noc3p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc2p-Noc3p complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleolar complex protein 2
Names
CG9246-PA
Noc2-PA
nucleolar complex protein-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21163641..21166090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136251.4 → NP_610095.1  nucleolar complex protein 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VIF0
    Related
    FBpp0081001
    Conserved Domains (1) summary
    pfam03715
    Location:344 → 641
    Noc2; Noc2p family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIF0.1 Q9VIF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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