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Zfp703 zinc finger protein 703 [ Mus musculus (house mouse) ]

Gene ID: 353310, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp703provided by MGI
Official Full Name
zinc finger protein 703provided by MGI
Primary source
MGI:MGI:2662729
See related
Ensembl:ENSMUSG00000085795 AllianceGenome:MGI:2662729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
End2; Zpo1; Csmn1; Zeppo1; Znf703; 1110032O19Rik
Summary
Enables DNA-binding transcription factor binding activity. Involved in several processes, including adherens junction assembly; positive regulation of mammary gland epithelial cell proliferation; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; eye; tooth; and urinary system. Orthologous to human ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 77.2), duodenum adult (RPKM 36.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp703 in Genome Data Viewer
Location:
8 A2; 8 15.91 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27467364..27471490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26977336..26981462)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1598 Neighboring gene predicted gene, 53408 Neighboring gene STARR-positive B cell enhancer ABC_E4993 Neighboring gene predicted gene, 39150 Neighboring gene predicted gene 45572 Neighboring gene STARR-seq mESC enhancer starr_21011 Neighboring gene predicted gene 45370 Neighboring gene predicted gene, 32389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression. Pereira-Castro I, et al. J Cell Biochem, 2013 Jan. PMID 22886885
  2. Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex. Kumar A, et al. Mol Cell Biol, 2016 Jun 15. PMID 27090637, Free PMC Article
  3. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Slorach EM, et al. Genes Dev, 2011 Mar 1. PMID 21317240, Free PMC Article
  4. ES cell neural differentiation reveals a substantial number of novel ESTs. Bain G, et al. Funct Integr Genomics, 2000 Sep. PMID 11793228
  5. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results provide evidence that Zfp703 is a novel feedback suppressor of Wnt/beta-catenin signaling that functions by inhibiting the association of beta-catenin with Tcf1 on Wnt response elements in target gene enhancers.
    Title: Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex.
  2. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.
    Title: Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression.
  3. Zeppo1 is a key regulator of breast cancer progression
    Title: Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to estradiol stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mammary gland epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mammary gland epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 703
Names
ES neuronal differentiation 2
zinc finger elbow-related proline domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101502.1 → NP_001094972.1  zinc finger protein 703 isoform 1

    See identical proteins and their annotated locations for NP_001094972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA008919, AC115820, BB609653, BE685996, BE981624, BF323167, BF464968, BQ964921, CD352751, CF582327
    Consensus CDS
    CCDS52532.1
    UniProtKB/Swiss-Prot
    P0CL69
    UniProtKB/TrEMBL
    F6M3K1
    Related
    ENSMUSP00000128757.2, ENSMUST00000154256.3
    Conserved Domains (2) summary
    sd00017
    Location:462 → 488
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12402
    Location:315 → 369
    nlz1; NocA-like zinc-finger protein 1

  2. NM_001110508.1 → NP_001103978.1  zinc finger protein 703 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional exon compared to transcript variant 1. This causes a frame-shift and early translation termination, resulting in a shorter isoform (2) with a different C-terminus compared to isoform 1.
    Source sequence(s)
    AA008919, AC115820, BB609653, BE685996, BE981624, BF323167, BF464968, BQ964921, CD352751, CF582327
    Consensus CDS
    CCDS52531.1
    UniProtKB/TrEMBL
    E9PXD8
    Related
    ENSMUSP00000132801.2, ENSMUST00000127097.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27467364..27471490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CL69.1 GenPept UniProtKB/Swiss-Prot:P0CL69

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