U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RtGEF Rho-type guanine nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35306, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
RtGEFprovided by FlyBase
Official Full Name
Rho-type guanine nucleotide exchange factorprovided by FlyBase
Primary source
FLYBASE:FBgn0015803
Locus tag
Dmel_CG10043
See related
AllianceGenome:FB:FBgn0015803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38C.40; ARHGEF7; beta-PIX; betaPIX; CG10043; Dmel\CG10043; dpix; dPix; dPIX; DrhoGEF; DrtGEF; pix; Pix; Rho/RacGEF; rhoGEF; RhoGEF; rtGEF
Summary
Enables molecular adaptor activity. Involved in negative regulation of organ growth; positive regulation of hippo signaling; and regulation of synapse organization. Located in muscle cell postsynaptic specialization. Is expressed in several structures, including amnioproctodeal invagination; embryonic/larval midgut primordium; epithelial furrow; female germline cell; and organism subdivision. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to several human genes including ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RtGEF in Genome Data Viewer
Location:
38C5-38C5; 2-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20350434..20365254)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20350434..20365254)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43606 Neighboring gene spire Neighboring gene La autoantigen-like Neighboring gene UDP-glycosyltransferase family 37 member A1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues. Werner LA, et al. Gene, 1997 Mar 10. PMID 9073073
  2. DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Hicks MS, et al. Dev Genes Evol, 2001 May. PMID 11455443
  3. Genetic analysis of a La homolog in Drosophila melanogaster. Bai C, et al. Nucleic Acids Res, 2000 Mar 1. PMID 10666446, Free PMC Article
  4. Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction. Ramos CI, et al. PLoS Genet, 2015 Apr. PMID 25905467, Free PMC Article
  5. The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development. Dent LG, et al. PLoS Genet, 2019 May. PMID 31116733, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pix and Git regulate Hippo-pathway-dependent tissue growth.
    Title: The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway.
  2. A novel RhoGEF(Pbl)-dependent input promotes the simultaneous association of anillin with the plasma membrane, septins, and microtubules, independently of F-actin.
    Title: Rho-dependent control of anillin behavior during cytokinesis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in muscle cell postsynaptic specialization IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Rho-type guanine nucleotide exchange factor
Names
CG10043-PA
CG10043-PB
CG10043-PD
CG10043-PE
CG10043-PF
CG10043-PG
CG10043-PH
CG10043-PI
PAK-interacting exchange factor
RtGEF-PA
RtGEF-PB
RtGEF-PD
RtGEF-PE
RtGEF-PF
RtGEF-PG
RtGEF-PH
RtGEF-PI
drosophila rho-type guanine exchange factor
rho-type guanine exchange factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20350434..20365254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103715.4 → NP_001097185.2  Rho-type guanine nucleotide exchange factor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097185.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ20
    Conserved Domains (5) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain
    pfam16614
    Location:543 → 610
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  2. NM_057826.5 → NP_477174.1  Rho-type guanine nucleotide exchange factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62527, Q9VIN1
    Related
    FBpp0080888
    Conserved Domains (5) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain
    pfam16614
    Location:543 → 610
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  3. NM_001169550.2 → NP_001163021.1  Rho-type guanine nucleotide exchange factor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163021.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C3KGL5, O62527
    Conserved Domains (5) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain
    pfam16614
    Location:543 → 610
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  4. NM_001273694.1 → NP_001260623.1  Rho-type guanine nucleotide exchange factor, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBE8
    Conserved Domains (4) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain

  5. NM_001103714.3 → NP_001097184.2  Rho-type guanine nucleotide exchange factor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097184.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ19
    Conserved Domains (3) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

  6. NM_165327.3 → NP_724258.1  Rho-type guanine nucleotide exchange factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724258.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62527, Q9VIN1
    Related
    FBpp0080889
    Conserved Domains (5) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain
    pfam16614
    Location:543 → 610
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  7. NM_001273693.1 → NP_001260622.1  Rho-type guanine nucleotide exchange factor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260622.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGB1
    Conserved Domains (5) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:294 → 372
    PH; PH domain
    pfam16614
    Location:543 → 610
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  8. NM_001382006.1 → NP_001369133.1  Rho-type guanine nucleotide exchange factor, isoform I [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ19
    Conserved Domains (3) summary
    cd11877
    Location:6 → 58
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:79 → 249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:281 → 376
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ19 A8DZ19
A8DZ20 A8DZ20
C3KGL5 C3KGL5
M9PBE8 M9PBE8
M9PGB1 M9PGB1
O62527 O62527
Q8SYV1 Q8SYV1
Q9VIN1 Q9VIN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous