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Pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35296, updated on 9-Dec-2024

Summary

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Official Symbol
Pyroxd1provided by FlyBase
Official Full Name
Pyridine nucleotide-disulfide oxidoreductase domain 1provided by FlyBase
Primary source
FLYBASE:FBgn0032846
Locus tag
Dmel_CG10721
See related
AllianceGenome:FB:FBgn0032846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38B.14; CG10721; Dmel\CG10721
Summary
Predicted to enable oxidoreductase activity. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Pyroxd1 in Genome Data Viewer
Location:
38B5-38B6; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20091435..20093152)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20091435..20093152)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nebbish Neighboring gene fledgling of Klp38B Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 13 Neighboring gene nessun dorma Neighboring gene mitochondrial ribosomal protein S18B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan. Saha M, et al. Physiol Genomics, 2018 Nov 1. PMID 30345904, Free PMC Article
  2. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
  3. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pyridine nucleotide-disulfide oxidoreductase domain 1
Names
CG10721-PA
CG10721-PB
Pyroxd1-PA
Pyroxd1-PB
NP_001260619.1
NP_610023.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20091435..20093152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273690.1 → NP_001260619.1  pyridine nucleotide-disulfide oxidoreductase domain 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260619.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VIP2
    Conserved Domains (1) summary
    pfam07992
    Location:8 → 355
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_136179.3 → NP_610023.1  pyridine nucleotide-disulfide oxidoreductase domain 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610023.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VIP2
    Related
    FBpp0080865
    Conserved Domains (1) summary
    pfam07992
    Location:8 → 355
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIP2.1 Q9VIP2

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