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neb nebbish [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35293, updated on 4-Jan-2025

Summary

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Official Symbol
nebprovided by FlyBase
Official Full Name
nebbishprovided by FlyBase
Primary source
FLYBASE:FBgn0004374
Locus tag
Dmel_CG10718
See related
AllianceGenome:FB:FBgn0004374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38B.10; 38B.12; CG10718; Dm0332; Dmel\CG10718; DmKlp38B; DmNeb; KIF 14; KIF14; KLP 38B; KLP-38B; Klp38; klp38B; Klp38B; KLP38B; l(2)03552; l(2)k00802; l(2)k07614; Mot; Neb; nebb; sl(2)ry; sl(2)ry3; tio
Summary
Enables protein phosphatase 1 binding activity. Involved in several processes, including follicle cell of egg chamber development; mitotic cell cycle, embryonic; and mitotic chromosome condensation. Located in heterochromatin. Is expressed in several structures, including follicle cell; ganglia; germline cell; gonad; and imaginal disc. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See neb in Genome Data Viewer
Location:
38B3-38B5; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20075757..20089698)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20075757..20089698)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene brain washing Neighboring gene uncharacterized protein Neighboring gene purple Neighboring gene fledgling of Klp38B Neighboring gene uncharacterized protein Neighboring gene Pyridine nucleotide-disulfide oxidoreductase domain 1 Neighboring gene TBP-associated factor 13 Neighboring gene nessun dorma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule motors in mitosis. Sharp DJ, et al. Nature, 2000 Sep 7. PMID 10993066
  2. A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. Molina I, et al. J Cell Biol, 1997 Dec 15. PMID 9396743, Free PMC Article
  3. Motor function in the mitotic spindle. Heald R. Cell, 2000 Aug 18. PMID 10966101
  4. Citron kinase controls a molecular network required for midbody formation in cytokinesis. Bassi ZI, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716662, Free PMC Article
  5. Identification of fat-cell enhancer activity in Drosophila melanogaster using P-element enhancer traps. Hoshizaki DK, et al. Genome, 1995 Jun. PMID 7557362

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding TAS
Traceable Author Statement
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables plus-end-directed microtubule motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation TAS
Traceable Author Statement
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nebbish
Names
CG10718-PA
Kinesin-like protein at 38B
Kinesin3C
mothra
neb-PA
tiovivo
NP_476817.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20075757..20089698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057469.4 → NP_476817.1  nebbish [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02030, O16866, O18389, Q9VIP4
    Related
    FBpp0080864
    Conserved Domains (4) summary
    smart00129
    Location:120 → 525
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:634 → 740
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:119 → 525
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:524 → 657
    Kinesin_assoc; Kinesin-associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16866 O16866
O18390 O18390
Q7JMZ1 Q7JMZ1
Q7KQ58 Q7KQ58
Q960F4 Q960F4
Q9VIP4 Q9VIP4

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