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Dus3 Dihydrouridine synthase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35264, updated on 4-Jan-2025

Summary

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Official Symbol
Dus3provided by FlyBase
Official Full Name
Dihydrouridine synthase 3provided by FlyBase
Primary source
FLYBASE:FBgn0032819
Locus tag
Dmel_CG10463
See related
AllianceGenome:FB:FBgn0032819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10463; Dmel\CG10463
Summary
Predicted to enable tRNA-dihydrouridine47 synthase activity. Predicted to be involved in tRNA processing. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Dus3 in Genome Data Viewer
Location:
38A2-38A2; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19758879..19760986)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19758879..19760986)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fructose-1,6-bisphosphatase Neighboring gene brain-specific homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
  2. Transcriptional regionalization of the fruit fly's airway epithelium. Faisal MN, et al. PLoS One, 2014. PMID 25020150, Free PMC Article
  3. Oviposition behaviour in Drosophila melanogaster: Genetic and behavioural decoupling between oviposition acceptance and preference for natural fruits. Fanara JJ, et al. J Evol Biol, 2023 Jan. PMID 36357966
  4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine47 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydrouridine synthase 3
Names
CG10463-PA
Dus3-PA
NP_610000.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19758879..19760986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136156.1 → NP_610000.1  dihydrouridine synthase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRT5, Q9VIS4
    Related
    FBpp0080828, FBtr0081290
    Conserved Domains (2) summary
    COG0042
    Location:253 → 547
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:258 → 492
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRT5 Q8MRT5
Q9VIS4 Q9VIS4

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