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Top3alpha - Topoisomerase 3alpha

Enables DNA topoisomerase activity. Involved in double-strand break repair via homologous recombination; mitochondrial genome maintenance; and tissue regeneration. Located in mitochondrial nucleoid and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa