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Top2 - Topoisomerase 2

Enables several functions, including ATP hydrolysis activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and nucleic acid binding activity. Involved in DNA topological change; heterochromatin formation; and nuclear chromosome segregation. Located in chromosome and nucleus. Colocalizes with condensed chromosome. Is expressed in adult head and adult heart. Orthologous to several human genes including TOP2B (DNA topoisomerase II beta). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to Top2

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Species Gene Architecture aa