amd alpha methyl dopa-resistant [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: amdprovided by FlyBase
Official Full Name: alpha methyl dopa-resistantprovided by FlyBase
Primary source: FLYBASE:FBgn0000075
Locus tag: Dmel_CG10501
See related: AllianceGenome:FB:FBgn0000075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AMD-r; CG10501; CG17345; Dmel\CG10501; fAMD; l(2)37Bk; l(2)amd; l(2)amd alpha-methyldopa hypersensitive; l(2)amd[H]; X04695
Summary: Enables 3,4-dihydroxyphenylacetaldehyde synthase activity. Involved in catecholamine metabolic process and chitin-based cuticle development. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; ganglia; gut section; imaginal disc; and larval tracheal system. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 37C1-37C1; 2-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19110154..19114110)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19110154..19114110)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3,4-dihydroxyphenylacetaldehyde synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	NAS Non-traceable Author Statement more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in catecholamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha methyl dopa-resistant

Names: 3,4-dihydroxyphenylacetaldehyde synthase; CG10501-PA; CG10501-PB; DHPA synthase; DHPAA synthase; alpha methyl dopa; alpha-methotrexate deficient; alpha-methyl dopa resistant; amd-PA; amd-PB; dopa decarboxylase; transcription unit No. 1

NP_476592.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.107

EC 4.1.1.28

NP_724162.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.107

EC 4.1.1.28

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19110154..19114110

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165278.2 → NP_724162.1 alpha methyl dopa-resistant, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724162.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BID9

Related

FBpp0080697

Conserved Domains (1) summary

pfam00282
Location:35 → 414

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
NM_057244.4 → NP_476592.1 alpha methyl dopa-resistant, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476592.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18486, Q9VIZ8, Q9VIZ9

UniProtKB/TrEMBL

C9QP35, H5V873

Related

FBpp0080698

Conserved Domains (1) summary

pfam00282
Location:35 → 414

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain