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Acn Acinus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35173, updated on 4-Jan-2025

Summary

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Official Symbol
Acnprovided by FlyBase
Official Full Name
Acinusprovided by FlyBase
Primary source
FLYBASE:FBgn0263198
Locus tag
Dmel_CG10473
See related
AllianceGenome:FB:FBgn0263198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
acn; Ba; CG10437; CG10473; dacn; dAcn; Dmel\CG10473; hkl; l(2)37Ba
Summary
Predicted to enable nucleic acid binding activity. Involved in RNA splicing and regulation of autophagy. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; adult head; central brain primordium; embryonic central brain neurons; and ganglia. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Acn in Genome Data Viewer
Location:
37B11-37B12; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19045355..19048817)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19045355..19048817)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb Neighboring gene Regulatory particle non-ATPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Optimized IMAC-IMAC protocol for phosphopeptide recovery from complex biological samples. Ye J, et al. J Proteome Res, 2010 Jul 2. PMID 20450229
  2. The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. Rigou P, et al. EMBO J, 2009 Jun 3. PMID 19387494, Free PMC Article
  3. The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Stathakis DG, et al. Genetics, 1999 Sep. PMID 10471719, Free PMC Article
  4. Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine(437). Nandi N, et al. Elife, 2017 Dec 11. PMID 29227247, Free PMC Article
  5. Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy. Nandi N, et al. J Cell Biol, 2014 Oct 27. PMID 25332163, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data indicate that Cdk5 is required to maintain the protective role of basal autophagy in the initial responses to a subset of neurodegenerative challenges via phosphorylating Acinus at serine 437.
    Title: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine(437).
  2. Study identified Drosophila acinus (dacn; hook-like), data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation.[Acinus]
    Title: Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.
  3. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
    Title: Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
acinus
Names
Acn-PA
Acn-PB
Acn-PC
CG10473-PA
CG10473-PB
CG10473-PC
drosophlia homolog of acinus
hook-like
lethal (2) 37Ba

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19045355..19048817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273627.1 → NP_001260556.1  acinus, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ12
    Conserved Domains (2) summary
    cd12432
    Location:444 → 530
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:600 → 691
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  2. NM_136091.4 → NP_609935.1  acinus, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ12
    Related
    FBpp0080689
    Conserved Domains (2) summary
    cd12432
    Location:444 → 530
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:600 → 691
    RSB_motif; RNSP1-SAP18 binding (RSB) motif

  3. NM_165273.2 → NP_724153.1  acinus, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ12
    Related
    FBpp0080688
    Conserved Domains (2) summary
    cd12432
    Location:444 → 530
    RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
    pfam16294
    Location:600 → 691
    RSB_motif; RNSP1-SAP18 binding (RSB) motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRH4 Q8MRH4
Q9VJ12 Q9VJ12

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