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Nak - Numb-associated kinase

Enables AP-2 adaptor complex binding activity and PTB domain binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of Notch signaling pathway; and regulation of clathrin-dependent endocytosis. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval midgut; gland; and nephrocyte. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa