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Sytalpha Synaptotagmin alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35068, updated on 4-Jan-2025

Summary

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Official Symbol
Sytalphaprovided by FlyBase
Official Full Name
Synaptotagmin alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0261089
Locus tag
Dmel_CG5559
See related
AllianceGenome:FB:FBgn0261089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5559; Dmel\CG5559; dsytalpha; Syt alpha; SYT-alpha; Syt3; SYT3; sytalpha
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Located in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Sytalpha in Genome Data Viewer
Location:
36D1-36D1; 2-53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17592260..17604387)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17592260..17604387)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44411 Neighboring gene long non-coding RNA:CR44410 Neighboring gene Olig family Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44412 Neighboring gene long non-coding RNA:CR44413

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Imambocus BN, et al. Curr Biol, 2022 Jan 10. PMID 34798050
  2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
  3. Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors. Oyallon J, et al. Dev Biol, 2012 Sep 15. PMID 22796650, Free PMC Article
  4. Function of Drosophila Synaptotagmins in membrane trafficking at synapses. Quiñones-Frías MC, et al. Cell Mol Life Sci, 2021 May. PMID 33619613, Free PMC Article
  5. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin alpha
Names
CG5559-PA
CG5559-PB
CG5559-PC
CG5559-PD
Syt3
Sytalpha-PA
Sytalpha-PB
Sytalpha-PC
Sytalpha-PD
sytalpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17592260..17604387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201903.1 → NP_001188832.1  synaptotagmin alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0HDP4
    Conserved Domains (2) summary
    cd00276
    Location:352 → 488
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cd08387
    Location:218 → 341
    C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

  2. NM_136009.2 → NP_609853.1  synaptotagmin alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7M6
    Related
    FBpp0080540
    Conserved Domains (2) summary
    cd00276
    Location:342 → 478
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cd08387
    Location:208 → 331
    C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

  3. NM_001299090.1 → NP_001286019.1  synaptotagmin alpha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286019.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7M6
    Conserved Domains (2) summary
    cd00276
    Location:342 → 478
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cd08387
    Location:208 → 331
    C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8

  4. NM_001201904.1 → NP_001188833.1  synaptotagmin alpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7M6
    Conserved Domains (2) summary
    cd00276
    Location:342 → 478
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cd08387
    Location:208 → 331
    C2A_Synaptotagmin-8; C2A domain first repeat present in Synaptotagmin 8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HDP4 C0HDP4
Q9I7M6 Q9I7M6

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