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cass cassowary [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35053, updated on 4-Jan-2025

Summary

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Official Symbol
cassprovided by FlyBase
Official Full Name
cassowaryprovided by FlyBase
Primary source
FLYBASE:FBgn0286781
Locus tag
Dmel_CG6582
See related
AllianceGenome:FB:FBgn0286781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAC-11; Aac11; Api5; bad; BcDNA.LD09852; BcDNA:LD09852; cas; CG6582; Dmel\CG6582; l(2)k06710
Summary
Predicted to enable RNA binding activity. Involved in negative regulation of apoptotic process. Predicted to be active in nucleus. Is expressed in adult head and organism. Orthologous to human API5 (apoptosis inhibitor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cass in Genome Data Viewer
Location:
36C9-36C10; 2-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17474912..17477888, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17474912..17477888, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bicaudal D Neighboring gene small glutamine-rich tetratricopeptide containing protein Neighboring gene four way stop Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene Glucosidase 2 beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. Rigou P, et al. EMBO J, 2009 Jun 3. PMID 19387494, Free PMC Article
  2. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
  3. dumpy interacts with a large number of genes in the developing wing of Drosophila melanogaster. Carmon A, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473031
  4. A screen to identify Drosophila genes required for integrin-mediated adhesion. Walsh EP, et al. Genetics, 1998 Oct. PMID 9755209, Free PMC Article
  5. The LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression. Huang Y, et al. PLoS One, 2007 Oct 31. PMID 17971870, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cassowary
Names
Aac11
CG6582-PA
antiapoptosis clone 11
antiapoptosis clone-11
apoptosis inhibitor-5
bladderwrack
cass-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17474912..17477888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058106.5 → NP_477454.1  cassowary [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V431
    Related
    FBpp0080554
    Conserved Domains (1) summary
    pfam05918
    Location:4 → 505
    API5; Apoptosis inhibitory protein 5 (API5)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V431.1 Q9V431

Gene LinkOut

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Chemical Information
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