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Sgt small glutamine-rich tetratricopeptide containing protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35052, updated on 4-Jan-2025

Summary

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Official Symbol
Sgtprovided by FlyBase
Official Full Name
small glutamine-rich tetratricopeptide containing proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032640
Locus tag
Dmel_CG5094
See related
AllianceGenome:FB:FBgn0032640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5094; Dmel\CG5094; dsgt; sgt
Summary
Predicted to enable molecular adaptor activity. Involved in positive regulation of chaperone-mediated protein folding. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in adult head and organism. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha) and SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Sgt in Genome Data Viewer
Location:
36C9-36C9; 2-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17471603..17474773)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17471603..17474773)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Serine protease homolog 93 Neighboring gene uncharacterized protein Neighboring gene Bicaudal D Neighboring gene cassowary Neighboring gene four way stop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
  2. Cysteine string proteins. Gundersen CB. Prog Neurobiol, 2020 May. PMID 32044380
  3. Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy. Khan A, et al. BMC Biol, 2020 Feb 14. PMID 32059717, Free PMC Article
  4. Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila. Sap KA, et al. J Proteome Res, 2017 Aug 4. PMID 28665616
  5. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Uytterhoeven V, et al. Neuron, 2015 Nov 18. PMID 26590345

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small glutamine-rich tetratricopeptide containing protein
Names
CG5094-PA
CG5094-PB
Sgt-PA
Sgt-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17471603..17474773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259129.2 → NP_001246058.1  small glutamine-rich tetratricopeptide containing protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJD4
    Conserved Domains (7) summary
    sd00006
    Location:116 → 144
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:184 → 217
    TPR_1; Tetratricopeptide repeat
    pfam07719
    Location:116 → 149
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:116 → 177
    TPR_11; TPR repeat
    pfam13431
    Location:139 → 170
    TPR_17; Tetratricopeptide repeat
    pfam13432
    Location:156 → 218
    TPR_16; Tetratricopeptide repeat
    pfam16546
    Location:9 → 48
    SGTA_dimer; Homodimerization domain of SGTA

  2. NM_135998.3 → NP_609842.1  small glutamine-rich tetratricopeptide containing protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJD4
    Related
    FBpp0080535
    Conserved Domains (7) summary
    sd00006
    Location:116 → 144
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:184 → 217
    TPR_1; Tetratricopeptide repeat
    pfam07719
    Location:116 → 149
    TPR_2; Tetratricopeptide repeat
    pfam13414
    Location:116 → 177
    TPR_11; TPR repeat
    pfam13431
    Location:139 → 170
    TPR_17; Tetratricopeptide repeat
    pfam13432
    Location:156 → 218
    TPR_16; Tetratricopeptide repeat
    pfam16546
    Location:9 → 48
    SGTA_dimer; Homodimerization domain of SGTA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJD4 Q9VJD4

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