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BicD - Bicaudal D

Enables cargo adaptor activity; clathrin heavy chain binding activity; and small GTPase binding activity. Involved in several processes, including mRNA transport; oocyte differentiation; and regulation of vesicle-mediated transport. Located in cytoplasm. Colocalizes with clathrin-coated endocytic vesicle membrane. Is expressed in several structures, including adult brain; embryonic/larval midgut primordium; epidermis; germline cell; and gut section. Used to study spinal muscular atrophy with lower extremity predominant 2A. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominant 2A and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to several human genes including BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]

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NCBI Orthologs

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Species Gene Architecture aa