dl - dorsal

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and high mobility group box 1 binding activity. Involved in several processes, including Toll signaling pathway; positive regulation of hemocyte proliferation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including cytosol; neuromuscular junction; and subsynaptic reticulum. Is expressed in several structures, including adult head; embryonic/larval hypodermal muscle cell; epithelium; germline cell; and neuromuscular junction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; primary immunodeficiency disease; and renal cell carcinoma. Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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