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grp grapes [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34993, updated on 4-Jan-2025

Summary

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Official Symbol
grpprovided by FlyBase
Official Full Name
grapesprovided by FlyBase
Primary source
FLYBASE:FBgn0261278
Locus tag
Dmel_CG17161
See related
AllianceGenome:FB:FBgn0261278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1C; CG17161; chk1; Chk1; CHK1; CHK1/Grapes; dChk1; Dchk1; DmChk1; Dmel\CG17161; grapes; Grp; grp(chk); Grp/DChk1; grps; l(2)k15102; lemp; Pk36A; Pk?1
Summary
Enables protein kinase activity. Involved in DNA integrity checkpoint signaling; microtubule cytoskeleton organization; and regulation of syncytial blastoderm mitotic cell cycle. Located in nucleus. Is expressed in adult brain; adult mushroom body; oocyte; organism; and primordial germ cell. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See grp in Genome Data Viewer
Location:
36A10-36A10; 2-52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16680054..16699926)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16680054..16699926)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel gamma Neighboring gene mir-2497 stem loop Neighboring gene hermaphrodite Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene squash Neighboring gene antisense RNA:CR44975 Neighboring gene mir-306 stem loop Neighboring gene mir-9c stem loop Neighboring gene mir-79 stem loop Neighboring gene mir-9b stem loop Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cytochrome c distal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Molecular evolution of mobile elements of the gypsy group: a homolog of the gag gene in Drosophila]. Nefedova LN, et al. Genetika, 2009 Jan. PMID 19239094
  2. Checkpoints on the road to mitosis. Russell P. Trends Biochem Sci, 1998 Oct. PMID 9810229
  3. The Drosophila maternal-effect mutation grapes causes a metaphase arrest at nuclear cycle 13. Fogarty P, et al. Development, 1994 Aug. PMID 7925016
  4. Modeling the role for nuclear import dynamics in the early embryonic cell cycle. Shindo Y, et al. Biophys J, 2021 Oct 5. PMID 34022240, Free PMC Article
  5. [Translational analysis of the Grp gene, a genomic homologue of the Gag gene of the gypsy retrotransposon of Drosophila melanogaster]. Kuz'min IV, et al. Genetika, 2011 Sep. PMID 22117415

See all (259) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
    Title: Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
  2. Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
    Title: Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
  3. The authors propose that ATR/Chk1 negatively regulate G2-M in developing tracheoblasts and that G2 arrest facilitates cellular and hypertrophic organ growth.
    Title: Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila.
  4. Grp was assumed to play a direct role in the immune response in D. melanogaster.
    Title: [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome].
  5. The Grp gene is expressed at the adult stage of D. melanogaster in gender-specific and tissue-specific manner.
    Title: Domesticated retroviral GAG gene in Drosophila: new functions for an old gene.
  6. Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
    Title: Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
  7. The Grp gene has been demonstrated to be a functional gene in the D. melanogaster genome, bit its function is yet to be determined.
    Title: [Translational analysis of the Grp gene, a genomic homologue of the Gag gene of the gypsy retrotransposon of Drosophila melanogaster].
  8. the Grp gene is not a pseudogene, but it is a functional gene of the D. melanogaster genome whose role remains to be elucidated.
    Title: [Transcriptional analysis of the Grp gene, a genomic homolog of the retrotransposon gypsy gag gene, in Drosophila melanogaster].
  9. A genetic screen identified grapes, the gene that encodes the Drosophila orthologue of checkpoint kinase 1 (CHK1). Knockdown of grapes by RNAi rescued eye development despite ongoing PERK activation.
    Title: Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.
  10. The Grp gene product has a highly conserved structure in different species of the Drosophilidae family and is under stabilizing selection, which suggests its important genomic function in Drosophila.
    Title: [Molecular evolution of mobile elements of the gypsy group: a homolog of the gag gene in Drosophila].
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
grapes
Names
CG17161-PA
CG17161-PB
CG17161-PC
CG17161-PD
CG17161-PF
Chk1/Grapes
Grapes/Chk1
checkpoint kinase 1
grp-PA
grp-PB
grp-PC
grp-PD
grp-PF
last empress
lethal (2) k15102
protein kinase-like 36A
NP_001260508.1
NP_477011.1
NP_723985.1
NP_723986.1
NP_723987.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16680054..16699926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165172.3 → NP_723986.1  grapes, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723986.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0S9, O61661, Q960N7
    Related
    FBpp0080442
    Conserved Domains (2) summary
    smart00220
    Location:22 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14069
    Location:20 → 279
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

  2. NM_165171.3 → NP_723985.1  grapes, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0S9, O61661, Q960N7
    Related
    FBpp0080441
    Conserved Domains (2) summary
    smart00220
    Location:22 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14069
    Location:20 → 279
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

  3. NM_001273579.1 → NP_001260508.1  grapes, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DY7
    Conserved Domains (2) summary
    smart00220
    Location:1 → 164
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 165
    PKc_like; Protein Kinases, catalytic domain

  4. NM_057663.4 → NP_477011.1  grapes, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477011.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0S9, O61661, Q960N7
    Related
    FBpp0080443
    Conserved Domains (2) summary
    smart00220
    Location:22 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14069
    Location:20 → 279
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

  5. NM_165173.3 → NP_723987.2  grapes, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723987.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DY7
    Conserved Domains (2) summary
    smart00220
    Location:1 → 164
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 165
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61661.2 O61661
Q59DY7 Q59DY7

Gene LinkOut

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