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ProtB Protamine B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34867, updated on 9-Dec-2024

Summary

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Official Symbol
ProtBprovided by FlyBase
Official Full Name
Protamine Bprovided by FlyBase
Primary source
FLYBASE:FBgn0013301
Locus tag
Dmel_CG4478
See related
AllianceGenome:FB:FBgn0013301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH11850; BG:DS03431.3; CG4478; Dmel\CG4478; dProtB; mst35b; Mst35Bb; MST35Bb; prot-B; protB
Summary
Involved in sperm DNA condensation. Located in chromatin. Is expressed in male germline cell and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ProtB in Genome Data Viewer
Location:
35B7-35B7; 2-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14882101..14883721, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14882101..14883721, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45727 Neighboring gene long non-coding RNA:CR45302 Neighboring gene Protamine A Neighboring gene sidestep II Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allelic Expression of Drosophila Protamines during Spermatogenesis. Kanippayoor RL, et al. Int J Evol Biol, 2012. PMID 22567534, Free PMC Article
  2. Last male sperm precedence is modulated by female remating rate in Drosophila melanogaster. Laturney M, et al. Evol Lett, 2018 Jun. PMID 30283675, Free PMC Article
  3. The role of HnrnpF/H as a driver of oligoteratozoospermia. Netherton JK, et al. iScience, 2024 Jul 19. PMID 39092172, Free PMC Article
  4. Chronic exposure to warm temperature causes low sperm abundance and quality in Drosophila melanogaster. Gandara ACP, et al. Sci Rep, 2023 Jul 30. PMID 37518578, Free PMC Article
  5. Ex vivo culture of Drosophila pupal testis and single male germ-line cysts: dissection, imaging, and pharmacological treatment. Gärtner SM, et al. J Vis Exp, 2014 Sep 11. PMID 25286189, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that Mst35B cooperates with Mst77F for the organization of sperm chromatin.
    Title: The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin.
  2. Quantity and quality of gametes were affected by the loss of Mst35B genes. Homozygous DeltaMst35B and DeltaMst35B/protDelta males were fertile.
    Title: Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.
  3. Expression of Mst77F, which is a specialized linker histone-like component of sperm chromatin, and of protamine B (ProtB), which contributes to formation of condensed sperm chromatin, is regulated at three levels.
    Title: Three levels of regulation lead to protamine and Mst77F expression in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in sperm DNA condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sperm DNA condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm DNA condensation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protamine B
Names
CG4478-PA
Male-specific-transcript-35Bb
ProtB-PA
ProtamineB
dProtamineB
protamine
protamine (mst35Bb)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14882101..14883721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057703.4 → NP_477051.1  protamine B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3U9, Q9VJR1
    Related
    FBpp0080243
    Conserved Domains (1) summary
    pfam06382
    Location:60 → 144
    DUF1074; Protein of unknown function (DUF1074)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24402 Q24402
Q24406 Q24406
Q9VJR1 Q9VJR1

Gene LinkOut

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