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CG3473 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34849, updated on 9-Dec-2024

Summary

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Official Symbol
CG3473provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0028913
Locus tag
Dmel_CG3473
See related
AllianceGenome:FB:FBgn0028913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT16033; BG:DS01486.1; cg3473; Dmel\CG3473; Ube2N
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in postreplication repair and protein K63-linked ubiquitination. Predicted to be part of ubiquitin conjugating enzyme complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N) and UBE2NL (ubiquitin conjugating enzyme E2 N like (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG3473 in Genome Data Viewer
Location:
35B3-35B3; 2-50 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14563015..14563726, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14563015..14563726, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44854 Neighboring gene long non-coding RNA:CR44855 Neighboring gene long non-coding RNA:CR44856 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
  2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. Hallacli E, et al. Mol Cell, 2012 Nov 30. PMID 23084835
  3. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. McPhee CK, et al. Cell Death Differ, 2013 Feb. PMID 22935612, Free PMC Article
  4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
  5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin conjugating enzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3473-PA
CG3473-PB
NP_001285937.1
NP_609715.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14563015..14563726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299008.1 → NP_001285937.1  uncharacterized protein Dmel_CG3473, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285937.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJS5
    Conserved Domains (2) summary
    COG5078
    Location:7 → 149
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cl00154
    Location:3 → 151
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_135871.3 → NP_609715.1  uncharacterized protein Dmel_CG3473, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609715.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJS5
    Related
    FBpp0080227
    Conserved Domains (2) summary
    COG5078
    Location:7 → 149
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cl00154
    Location:3 → 151
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJS5 Q9VJS5

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