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l(2)34Fc lethal (2) 34Fc [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34838, updated on 9-Dec-2024

Summary

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Official Symbol
l(2)34Fcprovided by FlyBase
Official Full Name
lethal (2) 34Fcprovided by FlyBase
Primary source
FLYBASE:FBgn0261534
Locus tag
Dmel_CG7532
See related
AllianceGenome:FB:FBgn0261534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A2; anon-EST:ParkEST060; BcDNA:RE60882; BG:DS01068.5; br8; CG7532; Dmel\CG7532; DS01068.5; l(2)br8; l34Fc
Summary
Involved in defense response to protozoan and negative regulation of immune response. Predicted to be located in extracellular region. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human REELD1 (reeler domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See l(2)34Fc in Genome Data Viewer
Location:
35A4-35A4; 2-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14349020..14351513, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14349020..14351513, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Spermathecal endopeptidase 2 Neighboring gene mitochondrial transcription termination factor Neighboring gene antisense RNA:CR44850 Neighboring gene uncharacterized protein Neighboring gene lethal (2) 34Fd Neighboring gene long non-coding RNA:CR44851 Neighboring gene Rab14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body. Zhu Y, et al. Insect Biochem Mol Biol, 2003 May. PMID 12706633
  2. A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster. Gubb D, et al. Genetics, 1988 Jun. PMID 3135239, Free PMC Article
  3. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Ashburner M, et al. Genetics, 1982 Nov. PMID 6816673, Free PMC Article
  4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
  5. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Gubb D, et al. Genetics, 1990 Sep. PMID 2121594, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal (2) 34Fc
Names
CG7532-PA
CG7532-PB
l(2)34Fc-PA
l(2)34Fc-PB
lethal 8 in the black-reduced region
lethal group A2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14349020..14351513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299001.1 → NP_001285930.1  lethal (2) 34Fc, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285930.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3Y3
    UniProtKB/TrEMBL
    X2J8E8
    Conserved Domains (1) summary
    pfam02014
    Location:27 → 149
    Reeler; Reeler domain

  2. NM_135866.4 → NP_609710.1  lethal (2) 34Fc, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3Y3
    UniProtKB/TrEMBL
    X2J8E8
    Related
    FBpp0080212
    Conserved Domains (1) summary
    pfam02014
    Location:27 → 149
    Reeler; Reeler domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3Y3.1 Q9V3Y3
X2J8E8 X2J8E8

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