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nAChRalpha5 nicotinic Acetylcholine Receptor alpha5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34826, updated on 4-Jan-2025

Summary

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Official Symbol
nAChRalpha5provided by FlyBase
Official Full Name
nicotinic Acetylcholine Receptor alpha5provided by FlyBase
Primary source
FLYBASE:FBgn0028875
Locus tag
Dmel_CG32975
See related
AllianceGenome:FB:FBgn0028875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AChRalpha5; anon-WO02059370.44; BG:DS05899.4; BG:DS05899.5; CG16878; CG32975; CG4498; CT14633; da5; daf; Dalpha5; Dmel\CG32975; lincRNA.128; lincRNA.S1055; nAChR; nAChRalpha-34E; nAcRalpha-34e; nAcRalpha-34E; Nic 34E
Summary
Enables acetylcholine binding activity. Contributes to acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport. Located in membrane. Part of acetylcholine-gated channel complex. Is expressed in DN1p neurons; adult head; and lamina monopolar neuron L4. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nAChRalpha5 in Genome Data Viewer
Location:
34F2-34F4; 2-50 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14040170..14094401)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14040170..14094401)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45284 Neighboring gene uncharacterized protein Neighboring gene heimdall Neighboring gene Nimrod C4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor. Wu P, et al. J Biol Chem, 2005 Jun 3. PMID 15781463, Free PMC Article
  2. Editing efficiency of a Drosophila gene correlates with a distant splice site selection. Agrawal R, et al. RNA, 2005 May. PMID 15840811, Free PMC Article
  3. The Drosophila nicotinic acetylcholine receptor subunits Dα5 and Dα7 form functional homomeric and heteromeric ion channels. Lansdell SJ, et al. BMC Neurosci, 2012 Jun 22. PMID 22727315, Free PMC Article
  4. Expression of insect α6-like nicotinic acetylcholine receptors in Drosophila melanogaster highlights a high level of conservation of the receptor:spinosyn interaction. Perry T, et al. Insect Biochem Mol Biol, 2015 Sep. PMID 25747008
  5. A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression. Watson GB, et al. Insect Biochem Mol Biol, 2010 May. PMID 19944756

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dalpha5 and Secreted Scaffold Protein Hig.
    Title: Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig.
  2. D alpha 5 is a component of an alpha-bungarotoxin binding nicotinic acetylcholine receptor from the central nervous system of Drosophila
    Title: The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinic acetylcholine receptor alpha5
Names
CG32975-PB
CG32975-PD
CG32975-PH
CG32975-PI
Dalpha5
nAChRalpha5-PB
nAChRalpha5-PD
nAChRalpha5-PH
nAChRalpha5-PI
nicotinic acetylcholine Receptor_34E
nicotinic acetylcholine receptor alpha 34E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14040170..14094401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_205985.3 → NP_995707.2  nicotinic acetylcholine receptor alpha5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995707.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT97, Q7KT98, Q8T7V5
    Conserved Domains (3) summary
    TIGR00860
    Location:313 → 802
    LIC; Cation transporter family protein
    pfam02931
    Location:313 → 520
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:527 → 797
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001370005.1 → NP_001356885.1  nicotinic acetylcholine receptor alpha5, isoform I [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A499GGQ3, Q8T7V5
    Conserved Domains (1) summary
    TIGR00860
    Location:313 → 802
    LIC; Cation transporter family protein

  3. NM_001259098.3 → NP_001246027.1  nicotinic acetylcholine receptor alpha5, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246027.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT97, Q7KT98, Q8T7V5
    Conserved Domains (3) summary
    TIGR00860
    Location:313 → 802
    LIC; Cation transporter family protein
    pfam02931
    Location:313 → 520
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:527 → 797
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. NM_205986.4 → NP_995708.1  nicotinic acetylcholine receptor alpha5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT97, Q7KT98, Q8T7V5
    Conserved Domains (3) summary
    TIGR00860
    Location:313 → 802
    LIC; Cation transporter family protein
    pfam02931
    Location:313 → 520
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:527 → 797
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A499GGQ3 A0A499GGQ3
Q7KT97 Q7KT97
Q8T5F5 Q8T5F5
Q8T7V5 Q8T7V5

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