U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CCL15-CCL14 CCL15-CCL14 readthrough (NMD candidate) [ Homo sapiens (human) ]

Gene ID: 348249, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CCL15-CCL14provided by HGNC
Official Full Name
CCL15-CCL14 readthrough (NMD candidate)provided by HGNC
Primary source
HGNC:HGNC:44436
See related
AllianceGenome:HGNC:44436
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIP5; NCC3; CCL15; HCC-2; LKN-1; MIP-5; NCC-3; Mrp-2b; SCYA15
Summary
A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts, but they are represented as non-coding because they are candidates for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Dec 2009]
Expression
Broad expression in spleen (RPKM 86.6), fat (RPKM 50.5) and 17 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CCL15-CCL14 in Genome Data Viewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35983656..36002038, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36931560..36949941, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34310692..34329084, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysozyme like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:34288003-34288221 Neighboring gene Sharpr-MPRA regulatory region 10414 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene C-C motif chemokine ligand 14 Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:34350127-34350628 Neighboring gene C-C motif chemokine ligand 23 Neighboring gene uncharacterized LOC105371746

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. Forssmann U, et al. J Leukoc Biol, 2001 Sep. PMID 11527984
  2. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Pardigol A, et al. Proc Natl Acad Sci U S A, 1998 May 26. PMID 9600961, Free PMC Article
  3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. Nomiyama H, et al. J Interferon Cytokine Res, 1999 Mar. PMID 10213461
  4. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Naruse K, et al. Genomics, 1996 Jun 1. PMID 8661057
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Markers

Homology

Other Names

  • C-C motif chemokine 15
  • CCL15-CCL14 readthrough (non-protein coding)
  • Chemokine CC-2
  • Leukotactin-1
  • MIP-1 delta
  • Macrophage inflammatory protein 5
  • Small-inducible cytokine A15

Clone Names

  • MGC176618

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027921.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in NM_032965, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC244100, Z70293

  2. NR_027922.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in NM_032965, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC244100, Z70292

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35983656..36002038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    218220..236612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36931560..36949941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_003025.1: Suppressed sequence

    Description
    NG_003025.1: This RefSeq was permanently suppressed because the two loci are no longer considered to be expressed from bicistronic transcripts, and NG_003025.1 is out of scope.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials