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b black [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34791, updated on 9-Dec-2024

Summary

Official Symbol
bprovided by FlyBase
Official Full Name
blackprovided by FlyBase
Primary source
FLYBASE:FBgn0000153
Locus tag
Dmel_CG7811
See related
AllianceGenome:FB:FBgn0000153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADC; ADC/CSADC; anon-34Db; B; BG:DS00941.5; Black; cDNA 1; CG7811; DGad2; Dm-ADC; Dmel\CG7811; DmGad2; Gad2; GAD[[2]]
Summary
Enables aspartate 1-decarboxylase activity and sulfinoalanine decarboxylase activity. Involved in visual behavior. Predicted to be active in cytoplasm. Is expressed in adult head; dorsal longitudinal indirect flight muscle cell; lamina; and mesothoracic tergotrochanter muscle cell. Orthologous to several human genes including CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

Location:
34D1-34D1; 2-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13821248..13823979)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13821248..13823979)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son of sevenless Neighboring gene DNA polymerase gamma subunit 1 Neighboring gene Actin-related protein 2/3 complex, subunit 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aspartate 1-decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aspartate 1-decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables glutamate decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfinoalanine decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in beta-alanine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
involved_in uracil catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in visual behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
black
Names
CG7811-PA
CG7811-PB
CG7811-PC
Oregon-R glutamate decarboxylase
aspartate 1-decarboxylase
aspartate decarboxylase
b-PA
b-PB
b-PC
cysteine sulfinic acid decarboxylase
glutamic acid decarboxylase 2
NP_001246025.1
NP_001285910.1
NP_476788.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13821248..13823979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259096.2NP_001246025.1  black, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24062
    Conserved Domains (1) summary
    cl18945
    Location:128499
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. NM_057440.5NP_476788.1  black, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24062
    Related
    FBpp0080119
    Conserved Domains (1) summary
    cl18945
    Location:128499
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. NM_001298981.1NP_001285910.1  black, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J8B3
    Conserved Domains (1) summary
    cl18945
    Location:67438
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...