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Adat1 Adenosine deaminase, tRNA-specific 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34787, updated on 4-Jan-2025

Summary

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Official Symbol
Adat1provided by FlyBase
Official Full Name
Adenosine deaminase, tRNA-specific 1provided by FlyBase
Primary source
FLYBASE:FBgn0028658
Locus tag
Dmel_CG16889
See related
AllianceGenome:FB:FBgn0028658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
adat; Adat; BG:DS00941.2; CG16889; dADAT1; Dmel\CG16889
Summary
Enables RNA binding activity and tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including ganglia; mesoderm; presumptive embryonic/larval central nervous system; and ventral neurectoderm. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Adat1 in Genome Data Viewer
Location:
34D1-34D1; 2-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13808360..13811474, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13808360..13811474, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Secretory 71 Neighboring gene Carbonic anhydrase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son of sevenless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Keegan LP, et al. Mol Cell Biol, 2000 Feb. PMID 10629039, Free PMC Article
  2. Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. Catanese DJ Jr, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21971547, Free PMC Article
  3. A-to-I RNA editing: recent news and residual mysteries. Maas S, et al. J Biol Chem, 2003 Jan 17. PMID 12446659
  4. RNA editing by base deamination: more enzymes, more targets, new mysteries. Gerber AP, et al. Trends Biochem Sci, 2001 Jun. PMID 11406411
  5. Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. Burgler C, et al. BMC Genomics, 2005 Jun 8. PMID 15943864, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DIP1-c was shown to interact with ADAT, a tRNA deaminase that presumably modifies pre-tRNAs.
    Title: Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosine deaminase, tRNA-specific 1
Names
Adat1-PA
Adat1-PB
CG16889-PA
CG16889-PB
adat
NP_001260450.1
NP_609676.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13808360..13811474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135832.3 → NP_609676.1  adenosine deaminase, tRNA-specific 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609676.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3R6
    UniProtKB/TrEMBL
    M9PDF5, N0BSY1
    Related
    FBpp0080150
    Conserved Domains (1) summary
    smart00552
    Location:7 → 389
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  2. NM_001273521.1 → NP_001260450.1  adenosine deaminase, tRNA-specific 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260450.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3R6
    UniProtKB/TrEMBL
    M9PDF5, N0BSY1
    Conserved Domains (1) summary
    smart00552
    Location:7 → 389
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDF5 M9PDF5
Q9V3R6.1 Q9V3R6

Gene LinkOut

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