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Tehao tehao [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34761, updated on 9-Dec-2024

Summary

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Official Symbol
Tehaoprovided by FlyBase
Official Full Name
tehaoprovided by FlyBase
Primary source
FLYBASE:FBgn0026760
Locus tag
Dmel_CG7121
See related
AllianceGenome:FB:FBgn0026760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7121; CT22017; Dmel\CG7121; dTLR5; dToll5; tehao; Tho; Tl-5; toll; Toll 5; Toll-5; Toll5
Summary
Enables Toll binding activity; coreceptor activity; and protein kinase binding activity. Involved in Toll signaling pathway; antifungal innate immune response; and positive regulation of antimicrobial peptide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval dorsal vessel; embryonic/larval salivary gland; gut section; keyhole structure; and ovary. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4) and TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tehao in Genome Data Viewer
Location:
34C1-34C1; 2-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13435622..13439930)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13435622..13439930)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45683 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene Heat shock protein 60D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
  2. Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans. Schlenke TA, et al. Genetics, 2005 Apr. PMID 15654108, Free PMC Article
  3. The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol. Atkinson NS. Cells, 2023 May 30. PMID 37296629, Free PMC Article
  4. Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. Lin KY, et al. Nat Commun, 2020 Jun 19. PMID 32561720, Free PMC Article
  5. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Luo C, et al. Insect Mol Biol, 2001 Oct. PMID 11881810

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hmu, Sr-CI/Sr-CIII, and Tehao have polymorphic sites in nearly perfect linkage disequilibrium
    Title: Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Toll binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Toll signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Toll signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in antifungal innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antimicrobial peptide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tehao
Names
CG7121-PA
CG7121-PB
Tehao-PA
Tehao-PB
Toll-5
toll 5
toll receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13435622..13439930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298972.1 → NP_001285901.1  tehao, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NBK8, Q9VJX9
    Conserved Domains (5) summary
    smart00255
    Location:643 → 779
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:261 → 370
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:185 → 207
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:486 → 521
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:309 → 368
    LRR_8; Leucine rich repeat

  2. NM_058090.4 → NP_477438.1  tehao, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NBK8, Q9VJX9
    Related
    FBpp0080080
    Conserved Domains (5) summary
    smart00255
    Location:643 → 779
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:261 → 370
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:185 → 207
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:486 → 521
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:309 → 368
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58S70 Q58S70
Q58S71 Q58S71
Q58S76 Q58S76
Q58SL2 Q58SL2
Q58SL5 Q58SL5
Q58SL6 Q58SL6
Q58SL7 Q58SL7
Q58SL8 Q58SL8
Q9NBK8 Q9NBK8
Q9VJX9 Q9VJX9
Q9XZF9 Q9XZF9

Gene LinkOut

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