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kek4 kekkon 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34718, updated on 4-Jan-2025

Summary

Official Symbol
kek4provided by FlyBase
Official Full Name
kekkon 4provided by FlyBase
Primary source
FLYBASE:FBgn0032484
Locus tag
Dmel_CG9431
See related
AllianceGenome:FB:FBgn0032484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9431; CT26742; Dmel\CG9431; kek-4
Summary
Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1) and LINGO2 (leucine rich repeat and Ig domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See kek4 in Genome Data Viewer
Location:
34A9-34A10; 2-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13212335..13215350, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13212335..13215350, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphoethanolamine cytidylyltransferase Neighboring gene small nuclear RNA U2 at 34AB a Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U2 at 34AB b Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

General protein information

Preferred Names
kekkon 4
Names
CG9431-PA
CG9431-PB
CG9431-PC
kek4-PA
kek4-PB
kek4-PC
kekkon-like
kekkon4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13212335..13215350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273507.1NP_001260436.1  kekkon 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK22
    Conserved Domains (5) summary
    cd00096
    Location:296387
    Ig; Immunoglobulin domain
    smart00410
    Location:294390
    IG_like; Immunoglobulin like
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99158
    LRR_8; Leucine rich repeat
    cl15307
    Location:228277
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. NM_001273506.1NP_001260435.1  kekkon 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK22
    Conserved Domains (5) summary
    cd00096
    Location:296387
    Ig; Immunoglobulin domain
    smart00410
    Location:294390
    IG_like; Immunoglobulin like
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99158
    LRR_8; Leucine rich repeat
    cl15307
    Location:228277
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. NM_135771.2NP_609615.2  kekkon 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609615.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK22
    Related
    FBpp0080064, FBtr0080485
    Conserved Domains (5) summary
    cd00096
    Location:296387
    Ig; Immunoglobulin domain
    smart00410
    Location:294390
    IG_like; Immunoglobulin like
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:99158
    LRR_8; Leucine rich repeat
    cl15307
    Location:228277
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain