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Ced-12 Ced-12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34633, updated on 9-Dec-2024

Summary

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Official Symbol
Ced-12provided by FlyBase
Official Full Name
Ced-12provided by FlyBase
Primary source
FLYBASE:FBgn0032409
Locus tag
Dmel_CG5336
See related
AllianceGenome:FB:FBgn0032409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ced-12; ced12; Ced12; CG5336; dced-12; dCed-12; dCED-12; Dced-12; dced12; dCed12; Dmel\CG5336; elmo; Elmo; ELMO
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including border follicle cell migration; imaginal disc fusion, thorax closure; and positive regulation of JNK cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including adult brain cell body rind; adult head; follicle cell; ganglia; and muscle cell. Orthologous to several human genes including ELMO1 (engulfment and cell motility 1) and ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ced-12 in Genome Data Viewer
Location:
33C4-33C4; 2-46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12097838..12100839)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12097838..12100839)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Peroxin 19 Neighboring gene uncharacterized protein Neighboring gene Methyltransferase 2 Neighboring gene patsas Neighboring gene Threonyl-tRNA synthetase Neighboring gene Rab6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular signaling of Dock family proteins in neural function. Miyamoto Y, et al. Cell Signal, 2010 Feb. PMID 19796679
  2. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
  3. Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila. Shiratsuchi A, et al. J Biol Chem, 2012 Jun 22. PMID 22547074, Free PMC Article
  4. QTL mapping of natural variation reveals that the developmental regulator bruno reduces tolerance to P-element transposition in the Drosophila female germline. Kelleher ES, et al. PLoS Biol, 2018 Oct. PMID 30376574, Free PMC Article
  5. Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge. Biersmith B, et al. Genetics, 2015 Jun. PMID 25908317, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The complex ELMO-Sponge is subapically enriched and is required for subapical restriction of Canoe in early embryos. The localization dynamics of ELMO-Sponge suggests a patterning mechanism for positioning the subapical region adjacent to the apical region.
    Title: ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos.
  2. Our results show that integrins function as upstream signals to mediate Dim7-Elmo enrichment to the muscle attachment sites .
    Title: Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.
  3. identified and characterized the role of Drosophila Sponge (Spg), the vertebrate DOCK3/DOCK4 counterpart as an ELMO-interacting protein
    Title: The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development.
  4. Overexpression of MBC and ELMO in the embryonic mesoderm causes defects in myoblast fusion reminiscent of those seen with constitutively-activated Rac1
    Title: Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ced-12
Names
CG5336-PA
Ced-12-PA
elmo
engulfment and cell motility

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12097838..12100839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135704.3 → NP_609548.1  Ced-12 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS15, Q9VKB2
    Related
    FBpp0079912
    Conserved Domains (3) summary
    cd13359
    Location:546 → 673
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:296 → 474
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:122 → 275
    DUF3361; Domain of unknown function (DUF3361)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS15 Q8MS15
Q9VKB2 Q9VKB2

Gene LinkOut

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