Rab3-GAP Rab3 GTPase activating protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab3-GAPprovided by FlyBase
Official Full Name: Rab3 GTPase activating proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0027505
Locus tag: Dmel_CG7061
See related: AllianceGenome:FB:FBgn0027505
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD23336; CG7061; Dmel\CG7061; rab3-GAP; Rab3GAP2
Summary: Predicted to enable small GTPase binding activity. Predicted to contribute to enzyme regulator activity. Involved in several processes, including macroautophagy; modulation of chemical synaptic transmission; and positive regulation of GTPase activity. Located in axon; presynaptic membrane; and vacuole. Is expressed in spermatozoon. Used to study Warburg micro syndrome. Human ortholog(s) of this gene implicated in Martsolf syndrome and Warburg micro syndrome 2. Orthologous to human RAB3GAP2 (RAB3 GTPase activating non-catalytic protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12058304..12063184, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12058304..12063184, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

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