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escl escl [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34611, updated on 9-Dec-2024

Summary

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Official Symbol
esclprovided by FlyBase
Official Full Name
esclprovided by FlyBase
Primary source
FLYBASE:FBgn0032391
Locus tag
Dmel_CG5202
See related
AllianceGenome:FB:FBgn0032391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5202; CG5202-PA; Dmel\CG5202; ESC; ESC-LIKE; ESC1; Escl; ESCL
Summary
Predicted to contribute to nucleosome binding activity. Involved in facultative heterochromatin formation. Part of ESC/E(Z) complex. Is expressed in eye disc; organism; salivary gland; and wing disc. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See escl in Genome Data Viewer
Location:
33B5-33B5; 2-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11990927..11992848)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11990927..11992848)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene zucchini Neighboring gene dim gamma-tubulin 2 Neighboring gene transcriptional Adaptor 1-2 Neighboring gene uncharacterized protein Neighboring gene Quetzalcoatl

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Kurzhals RL, et al. Dev Biol, 2008 Jan 1. PMID 18048023, Free PMC Article
  2. Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Coleman RT, et al. Science, 2017 Apr 7. PMID 28302795, Free PMC Article
  3. Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Rogers RL, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534482, Free PMC Article
  4. Role of the polycomb protein EED in the propagation of repressive histone marks. Margueron R, et al. Nature, 2009 Oct 8. PMID 19767730, Free PMC Article
  5. The Polycomb complex PRC2 and its mark in life. Margueron R, et al. Nature, 2011 Jan 20. PMID 21248841, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the roles of ESC and ESCL in Polycomb Group mechanisms
    Title: ESC, ESCL and their roles in Polycomb Group mechanisms.
  2. These data thus indicate that ESC and ESCL play similar if not identical functions in E(Z) complexes in vivo.
    Title: Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in facultative heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
escl
Names
CG5202-PA
CG5202-PC
esc-like
escl-PA
escl-PC
extra sex comb like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11990927..11992848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164979.2 → NP_723702.1  escl, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKD5
    Related
    FBpp0079870
    Conserved Domains (3) summary
    COG2319
    Location:96 → 459
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:111 → 158
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:107 → 352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001298928.1 → NP_001285857.1  escl, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKD5
    Conserved Domains (3) summary
    COG2319
    Location:96 → 459
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:111 → 158
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:107 → 352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SW6 Q95SW6
Q9VKD5 Q9VKD5

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