U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CycY Cyclin Y [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34593, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CycYprovided by FlyBase
Official Full Name
Cyclin Yprovided by FlyBase
Primary source
FLYBASE:FBgn0032378
Locus tag
Dmel_CG14939
See related
AllianceGenome:FB:FBgn0032378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.165; CG14939; Dcyclin Y; Dmel\CG14939; i182
Summary
Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in developmental growth and positive regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head and organism. Orthologous to several human genes including CCNY (cyclin Y). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CycY in Genome Data Viewer
Location:
33A2-33A2; 2-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11810092..11813780, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11810092..11813780, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene crooked legs Neighboring gene Phosphodiesterase 1c Neighboring gene uncharacterized protein Neighboring gene extra sexcombs

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Liu D, et al. Genetics, 2010 Apr. PMID 20100936, Free PMC Article
  2. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949
  3. Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster. Szlanka T, et al. G3 (Bethesda), 2024 Sep 4. PMID 38985658, Free PMC Article
  4. Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP. Battersby A, et al. J Mol Biol, 2003 Jun 6. PMID 12767830
  5. Genome-wide identification of phospho-regulators of Wnt signaling in Drosophila. Swarup S, et al. Development, 2015 Apr 15. PMID 25852200

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CycY/Eip63E form a cyclin/Cdk complex that is essential for several developmental processes.
    Title: Cyclin Y is a novel conserved cyclin essential for development in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cyclin Y
Names
CG14939-PA
CG14939-PB
CycY-PA
CycY-PB
drosophila cyclin Y

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11810092..11813780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273465.1 → NP_001260394.1  cyclin Y, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKF0
    Conserved Domains (1) summary
    pfam00134
    Location:205 → 327
    Cyclin_N; Cyclin, N-terminal domain

  2. NM_135675.4 → NP_609519.1  cyclin Y, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKF0
    Related
    FBpp0079843
    Conserved Domains (1) summary
    pfam00134
    Location:205 → 327
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKF0 Q9VKF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools