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salm - spalt major

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neurogenesis; open tracheal system development; and regulation of RNA metabolic process. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; glial cell; parasegment; and photoreceptor neurons. Used to study carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; and coloboma. Orthologous to several human genes including SALL3 (spalt like transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa