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Osi21 Osiris 21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34566, updated on 9-Dec-2024

Summary

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Official Symbol
Osi21provided by FlyBase
Official Full Name
Osiris 21provided by FlyBase
Primary source
FLYBASE:FBgn0283678
Locus tag
Dmel_CG14925
See related
AllianceGenome:FB:FBgn0283678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14925; die4; diehard4; Dmel\CG14925
Summary
Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Osi21 in Genome Data Viewer
Location:
32E2-32E2; 2-44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11284327..11285706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11284327..11285706, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44182 Neighboring gene uncharacterized protein Neighboring gene Palmitoyl-protein Thioesterase 2 Neighboring gene meiotic recombination 11 Neighboring gene long non-coding RNA:CR43409 Neighboring gene long non-coding RNA:CR43721

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Ciapponi L, et al. Curr Biol, 2004 Aug 10. PMID 15296753
  2. Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. Lee J, et al. PLoS Genet, 2013 Jun. PMID 23754968, Free PMC Article
  3. MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1. Guven-Ozkan T, et al. Cell Rep, 2016 Feb 23. PMID 26876166, Free PMC Article
  4. Tracheal expression of Osiris gene family in Drosophila. Scholl A, et al. Gene Expr Patterns, 2018 Jun. PMID 29548969
  5. Conserved roles of Osiris genes in insect development, polymorphism and protection. Smith CR, et al. J Evol Biol, 2018 Apr. PMID 29322640

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found that diehard4 encodes Osiris 21... Loss of its function suppresses retinal degeneration
    Title: Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
osiris 21
Names
CG14925-PA
Osi21-PA
diehard4
osiris

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11284327..11285706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135657.3 → NP_609501.1  osiris 21 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKH5
    Related
    FBpp0079803
    Conserved Domains (1) summary
    pfam07898
    Location:79 → 152
    DUF1676; Protein of unknown function (DUF1676)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKH5 Q9VKH5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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