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hgo homogentisate 1,2-dioxygenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34552, updated on 4-Jan-2025

Summary

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Official Symbol
hgoprovided by FlyBase
Official Full Name
homogentisate 1,2-dioxygenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0040211
Locus tag
Dmel_CG4779
See related
AllianceGenome:FB:FBgn0040211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4779; Dmel\CG4779; Hgo; HGO
Summary
Predicted to enable homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Is expressed in adult head; dorsal imaginal tissue; embryonic dorsal epidermis; and embryonic ventral epidermis. Used to study alkaptonuria. Human ortholog(s) of this gene implicated in alkaptonuria. Orthologous to human HGD (homogentisate 1,2-dioxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See hgo in Genome Data Viewer
Location:
32D5-32D5; 2-44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11136393..11138565)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11136393..11138565)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nucleoporin 160kD Neighboring gene Replication factor C 38kD subunit Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 32E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
  2. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
  3. Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development. Nevil M, et al. Genetics, 2017 Feb. PMID 28007888, Free PMC Article
  4. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article
  5. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. Ren J, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653638, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables homogentisate 1,2-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables homogentisate 1,2-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homogentisate 1,2-dioxygenase
Names
CG4779-PA
hgo-PA
NP_523544.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11136393..11138565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078820.3 → NP_523544.2  homogentisate 1,2-dioxygenase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523544.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86P40, Q9VKJ0
    Related
    FBpp0079790
    Conserved Domains (1) summary
    TIGR01015
    Location:3 → 434
    hmgA; homogentisate 1,2-dioxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKJ0.3 Q9VKJ0

Gene LinkOut

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