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Nup160 Nucleoporin 160kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34549, updated on 4-Jan-2025

Summary

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Official Symbol
Nup160provided by FlyBase
Official Full Name
Nucleoporin 160kDprovided by FlyBase
Primary source
FLYBASE:FBgn0262647
Locus tag
Dmel_CG4738
See related
AllianceGenome:FB:FBgn0262647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4738; Dmel\CG4738; l(2)SH2 2055; l(2)SH2055; Nup; nup160; Nup160[mel]
Summary
Predicted to be a structural constituent of nuclear pore. Involved in double-strand break repair via homologous recombination; protein import into nucleus; and regulation of nucleocytoplasmic transport. Part of nuclear pore. Is expressed in adult head. Used to study nephrotic syndrome type 19. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nup160 in Genome Data Viewer
Location:
32D4-32D4; 2-44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11123777..11129335)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11123777..11129335)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynein axonemal assembly factor 4 Neighboring gene Csl4 Neighboring gene Replication factor C 38kD subunit Neighboring gene uncharacterized protein Neighboring gene homogentisate 1,2-dioxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A test of double interspecific introgression of nucleoporin genes in Drosophila. Sawamura K, et al. G3 (Bethesda), 2014 Aug 28. PMID 25172915, Free PMC Article
  2. Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome. Zhao F, et al. J Am Soc Nephrol, 2019 May. PMID 30910934, Free PMC Article
  3. Roles of mutation and selection in speciation: from Hugo de Vries to the modern genomic era. Nei M, et al. Genome Biol Evol, 2011. PMID 21903731, Free PMC Article
  4. Lineage-Specific Evolution of the Complex Nup160 Hybrid Incompatibility Between Drosophila melanogaster and Its Sister Species. Tang S, et al. Genetics, 2015 Aug. PMID 26022241, Free PMC Article
  5. Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes. Choi JY, et al. Genome Biol Evol, 2015 Oct 27. PMID 26507797, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Nup160sim gene is apparently involved in multiple reproductive isolation phenotypes in the cross between D. melanogaster and D. simulans.
    Title: Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila.
  2. Introduction of nuclear pore protein 160 (Nup160) from Drosophila simulans into Drosophila melanogaster caused female sterility in homozygous or hemizygous progeny.
    Title: Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore outer ring ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleoporin 160kD
Names
CG4738-PA
CG4738-PB
Nup160-PA
Nup160-PB
lethal (2) SH2055
nuclear pore protein 160
nucleoporin 160

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11123777..11129335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135649.2 → NP_609493.1  nucleoporin 160kD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0KG65, C0KG66, C0KG67, C0KG68, C0KG69, C0KG70, C0KG71, C0KG74, C0KG75, Q6AWI7, Q9VKJ3
    UniProtKB/TrEMBL
    X2J9F3
    Related
    FBpp0079788
    Conserved Domains (1) summary
    pfam11715
    Location:28 → 530
    Nup160; Nucleoporin Nup120/160

  2. NM_001298903.1 → NP_001285832.1  nucleoporin 160kD, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285832.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0KG65, C0KG66, C0KG67, C0KG68, C0KG69, C0KG70, C0KG71, C0KG74, C0KG75, Q6AWI7, Q9VKJ3
    UniProtKB/TrEMBL
    X2J9F3
    Conserved Domains (1) summary
    pfam11715
    Location:28 → 530
    Nup160; Nucleoporin Nup120/160
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKJ3.1 Q9VKJ3
X2J9F3 X2J9F3

Gene LinkOut

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