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Ge-1 Ge-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34541, updated on 4-Jan-2025

Summary

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Official Symbol
Ge-1provided by FlyBase
Official Full Name
Ge-1provided by FlyBase
Primary source
FLYBASE:FBgn0283682
Locus tag
Dmel_CG6181
See related
AllianceGenome:FB:FBgn0283682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6181; dGe-1; Dmel\CG6181; EDC4; GE-1; ref(2)M; Ref(2)Me
Summary
Involved in several processes, including P-body assembly; pole plasm oskar mRNA localization; and post-transcriptional regulation of gene expression. Located in P-body and pole plasm. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; female germline cell; and ganglia. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ge-1 in Genome Data Viewer
Location:
32D3-32D3; 2-44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11095150..11100888, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11095150..11100888, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene WD repeat domain 59 Neighboring gene RALBP1 associated Eps domain containing Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Why do Individuals Differ in Viral Susceptibility? A Story Told by Model Organisms. van Sluijs L, et al. Viruses, 2017 Sep 30. PMID 28973976, Free PMC Article
  2. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Jinek M, et al. RNA, 2008 Oct. PMID 18755833, Free PMC Article
  3. [Drosophila genes which intervene in multiplication of sigma virus (author's transl)]. Gay P. Mol Gen Genet, 1978 Feb 27. PMID 416336
  4. HPat a decapping activator interacting with the miRNA effector complex. Barišić-Jäger E, et al. PLoS One, 2013. PMID 23977167, Free PMC Article
  5. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we identified a deletion in the protein-coding region of a gene called Ge-1 in flies that are highly resistant to a naturally occurring virus called sigma virus
    Title: A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in Drosophila.
  2. Findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo.
    Title: Drosophila Ge-1 promotes P body formation and oskar mRNA localization.
  3. The three-dimensional crystal structure of the most conserved region of the Drosophila melanogaster Ge-1 C-terminal domain was determined.
    Title: The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pole plasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ge-1
Names
CG6181-PA
CG6181-PB
Ge-1 ortholog
Ge-1-PA
Ge-1-PB
refractory to sigma M

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11095150..11100888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164957.2 → NP_723654.1  Ge-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723654.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MZ42, Q9VKK1
    Related
    FBpp0079819
    Conserved Domains (3) summary
    pfam16529
    Location:119 → 452
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:144 → 185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:314 → 444
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_135642.3 → NP_609486.2  Ge-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609486.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MZ42, Q9VKK1
    Related
    FBpp0079818
    Conserved Domains (3) summary
    pfam16529
    Location:119 → 452
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:144 → 185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:314 → 444
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKK1.2 Q9VKK1

Gene LinkOut

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