U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AstC Allatostatin C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34537, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
AstCprovided by FlyBase
Official Full Name
Allatostatin Cprovided by FlyBase
Primary source
FLYBASE:FBgn0032336
Locus tag
Dmel_CG14919
See related
AllianceGenome:FB:FBgn0032336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ASC; Ast-C; AST-C; ast2; Ast2; ASTC; BcDNA:RH36507; BEST:GH06087; CG14919; CG149199; DAP-C; Dmel\CG14919; Drm-AST-C; flt; Flt; FLT; gh06087; M-ASH
Summary
Enables myoinhibitory hormone activity. Involved in negative regulation of feeding behavior and negative regulation of heart rate. Located in extracellular space. Is expressed in several structures, including adult pacemaker neurons; central nervous system; crop; embryonic brain; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AstC in Genome Data Viewer
Location:
32D2-32D2; 2-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11076165..11081399, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11076165..11081399, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45725 Neighboring gene uncharacterized protein Neighboring gene Allatostatin double C Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin. Price MD, et al. Peptides, 2002 Apr. PMID 11897399
  2. Molecular cloning, genomic organization, and expression of a C-type (Manduca sexta-type) allatostatin preprohormone from Drosophila melanogaster. Williamson M, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263981
  3. The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ. Kaminski S, et al. J Neurogenet, 2002 Apr-Jun. PMID 12479379
  4. Drosophila melanogaster myotropins have unique functions and signaling pathways. Merte J, et al. Peptides, 2002 Apr. PMID 11897395
  5. Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila. Díaz MM, et al. Curr Biol, 2019 Jan 7. PMID 30554904, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.
    Title: The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.
  2. The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis.
    Title: The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis.
  3. Clock-neuron-derived AstC is required to mediate evening locomotor activity under short (winter-like) and long (summer-like) photoperiods. The AstC-Receptor 2 (AstC-R2) is expressed in dorsal-lateral neurons, the clock neurons that drive evening locomotor activity, and AstC-R2 is required in these neurons to modulate the same short photoperiod evening phenotype.
    Title: Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila.
  4. molecular characterization; measured activity indicates that it is a potent myotropin
    Title: Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables myoinhibitory hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of heart rate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of juvenile hormone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT involved_in negative regulation of juvenile hormone biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
allatostatin C
Names
AstC-PA
AstC-PB
CG14919-PA
CG14919-PB
Drm-AST C
Drostatin-C
allatostatin 2
allatostatin Manduca-type
allatostatin-C
flatline

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11076165..11081399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169477.3 → NP_001162948.1  allatostatin C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95NV8

  2. NM_078818.5 → NP_523542.1  allatostatin C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKK5
    Related
    FBpp0079821
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95NV8 Q95NV8
Q9VKK5 Q9VKK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools