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Samuel SAM-motif ubiquitously expressed punctatedly localized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34530, updated on 9-Dec-2024

Summary

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Official Symbol
Samuelprovided by FlyBase
Official Full Name
SAM-motif ubiquitously expressed punctatedly localized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032330
Locus tag
Dmel_CG31868
See related
AllianceGenome:FB:FBgn0032330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
78BP; CG12291; CG14917; CG14918; CG31868; Dmel\CG31868; mdcds_1002; moses; Moses
Summary
Predicted to enable chromatin binding activity and histone binding activity. Involved in regulation of growth. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Is expressed in adult tracheal system. Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human SAMD11 (sterile alpha motif domain containing 11) and SAMD7 (sterile alpha motif domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Samuel in Genome Data Viewer
Location:
32C1-32D1; 2-44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11013206..11066998, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11013206..11066998, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45778 Neighboring gene Nucleoporin 154kD Neighboring gene Deoxyuridine triphosphatase Neighboring gene Arginine methyltransferase 8 Neighboring gene Accessory gland protein 32CD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46264 Neighboring gene long non-coding RNA:CR45725 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Baker KD, et al. Genes Dev, 2007 Feb 15. PMID 17322404, Free PMC Article
  2. Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Peterson AJ, et al. Genetics, 2004 Jul. PMID 15280237, Free PMC Article
  3. Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance. Schneiderman JI, et al. PLoS Genet, 2010 Sep 9. PMID 20838586, Free PMC Article
  4. Single-nucleus RNA-sequencing in pre-cellularization Drosophila melanogaster embryos. Albright AR, et al. PLoS One, 2022. PMID 35749552, Free PMC Article
  5. Comparative genomics of accessory gland protein genes in Drosophila melanogaster and D. pseudoobscura. Wagstaff BJ, et al. Mol Biol Evol, 2005 Apr. PMID 15601888

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DHR78 and Moses proteins are coexpressed during development and colocalize to specific genomic targets in chromatin.
    Title: Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SAM-motif ubiquitously expressed punctatedly localized protein
Names
CG31868-PA
CG31868-PB
CG31868-PD
CG31868-PE
Samuel-PA
Samuel-PB
Samuel-PD
Samuel-PE
middleman of seventy-eight signaling

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11013206..11066998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080362.4 → NP_525101.2  SAM-motif ubiquitously expressed punctatedly localized protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525101.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0MSJ4, Q9VKL0
    Related
    FBpp0079750
    Conserved Domains (2) summary
    cd09579
    Location:795 → 862
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
    smart00454
    Location:795 → 852
    SAM; Sterile alpha motif

  2. NM_001273443.3 → NP_001260372.1  SAM-motif ubiquitously expressed punctatedly localized protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260372.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0MSJ4, Q9VKL0
    Conserved Domains (2) summary
    cd09579
    Location:795 → 862
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
    smart00454
    Location:795 → 852
    SAM; Sterile alpha motif

  3. NM_001298899.1 → NP_001285828.1  SAM-motif ubiquitously expressed punctatedly localized protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0MSJ4, M9PB98, X2JA41
    Conserved Domains (1) summary
    cl15755
    Location:795 → 823
    SAM_superfamily; SAM (Sterile alpha motif )

  4. NM_001273444.3 → NP_001260373.2  SAM-motif ubiquitously expressed punctatedly localized protein, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0MSJ4, M9PB98, X2JA41
    Conserved Domains (1) summary
    cl15755
    Location:795 → 823
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0MSJ4 A0MSJ4
M9PB98 M9PB98
Q9VKL0 Q9VKL0

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