Nup154 Nucleoporin 154kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup154provided by FlyBase
Official Full Name: Nucleoporin 154kDprovided by FlyBase
Primary source: FLYBASE:FBgn0021761
Locus tag: Dmel_CG4579
See related: AllianceGenome:FB:FBgn0021761
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD21772; CG4579; Dmel\CG4579; l(2)01501; l(2)10432; ms(2)zk; Nup; nup154; NUP154; Nup155; nup32D; Nup32D; tip; tlp; zk
Summary: Enables chromatin binding activity. Involved in several processes, including oogenesis; protein localization to nuclear inner membrane; and regulation of protein localization. Located in cytoplasm; nuclear envelope; and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including adult head; egg chamber; germline cell; gut section; and supraesophageal ganglion. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 32C1-32C1; 2-44 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (11004820..11010921)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (11004820..11010921)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of Nup155 in inner nuclear membrane protein localisation is not mediated through the nuclear pore complexes anchoring activity of the protein.
Title: The Nup155-mediated organisation of inner nuclear membrane proteins is independent of Nup155 anchoring to the metazoan nuclear pore complex.
Nucleoporin Nup154 is required for cell survival and proliferation - Nup154 controls nuclear localization of Mad transcription factor, but does not interact directly with it
Title: Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor.
We propose that Nup154 is necessary for correct nuclear pore complex functions and that the proper regulation of the actin cytoskeleton dynamics strongly relies upon nuclear pore integrity.
Title: The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis.
cup, nup154 double mutants exhibit much stronger oogenesis defects than single mutants
Title: nup154 genetically interacts with cup and plays a cell-type-specific function during Drosophila melanogaster egg-chamber development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0669 (e-PCR)
- UniSTS:34492

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in oocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte growth in germarium-derived egg chamber	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore inner ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleoporin 154kD

Names: CG4579-PA; CG4579-PC; CG4579-PD; Nup154-PA; Nup154-PC; Nup154-PD; nucleoporin 154; tulipano; zonder kloten

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

11004820..11010921

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298898.1 → NP_001285827.1 nucleoporin 154kD, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285827.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62536, O62610, O62613, Q9V463, Q9VKL5

Conserved Domains (2) summary

pfam03177
Location:1018 → 1139

Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

pfam08801
Location:66 → 502

Nucleoporin_N; Nup133 N terminal like
NM_057940.4 → NP_477288.3 nucleoporin 154kD, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477288.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O62536, O62610, O62613, Q9V463, Q9VKL5

Conserved Domains (2) summary

pfam03177
Location:1018 → 1139

Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

pfam08801
Location:66 → 502

Nucleoporin_N; Nup133 N terminal like
NM_057939.4 → NP_477287.1 nucleoporin 154kD, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477287.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62536, O62610, O62613, Q9V463, Q9VKL5

Related

FBpp0088820

Conserved Domains (2) summary

pfam03177
Location:1018 → 1139

Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

pfam08801
Location:66 → 502

Nucleoporin_N; Nup133 N terminal like