U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stam Signal transducing adaptor molecule [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34505, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Stamprovided by FlyBase
Official Full Name
Signal transducing adaptor moleculeprovided by FlyBase
Primary source
FLYBASE:FBgn0027363
Locus tag
Dmel_CG6521
See related
AllianceGenome:FB:FBgn0027363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6521; Dmel\CG6521; dstam; Dstam; stam; STAM; Stam1
Summary
Predicted to enable ubiquitin binding activity. Involved in several processes, including epithelial cell migration, open tracheal system; neuron remodeling; and regulation of epithelial cell migration, open tracheal system. Predicted to be part of ESCRT-0 complex. Is expressed in several structures, including female germline cell; ganglia; larval ventral midline glial cell; midline primordium; and ventral midline of embryo. Orthologous to several human genes including STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Stam in Genome Data Viewer
Location:
32B2-32B3; 2-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10858536..10862006)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10858536..10862006)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 3 Neighboring gene DNZDHHC/NEW1 zinc finger protein 11 Neighboring gene aurora B Neighboring gene long non-coding RNA:CR43807 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. Lohi O, et al. FEBS Lett, 2001 Nov 23. PMID 11728436
  2. VHS domain -- a longshoreman of vesicle lines. Lohi O, et al. FEBS Lett, 2002 Feb 20. PMID 11911875
  3. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Bischoff JR, et al. Trends Cell Biol, 1999 Nov. PMID 10511710
  4. dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster. Galasso A, et al. Gene Expr Patterns, 2007 Aug. PMID 17664083
  5. Depletion of ESCRT ameliorates APP-induced AD-like symptoms in Drosophila. Zhuang L, et al. J Cell Physiol, 2023 Jul. PMID 37183375

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
    Title: ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.
  2. 2 Drosophila epithelia lacking Stam, or Hrs and Stam, accumulate Notch and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch signaling activation.
    Title: ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
  3. analysis of dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster
    Title: dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
part_of ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT-0 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
signal transducing adaptor molecule
Names
CG6521-PA
Stam-PA
signal transducer adaptor molecule
signal-transducing adaptor molecule

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10858536..10862006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058100.4 → NP_477448.1  signal transducing adaptor molecule [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTL2
    Related
    FBpp0079732
    Conserved Domains (3) summary
    cd11820
    Location:235 → 288
    SH3_STAM; Src homology 3 domain of Signal Transducing Adaptor Molecules
    cd03568
    Location:10 → 154
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam03127
    Location:340 → 412
    GAT; GAT domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTL2 Q9XTL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous