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CG6508 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34493, updated on 9-Dec-2024

Summary

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Official Symbol
CG6508provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032303
Locus tag
Dmel_CG6508
See related
AllianceGenome:FB:FBgn0032303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6508
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be active in lysosome. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6508 in Genome Data Viewer
Location:
32B1-32B1; 2-43 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10819107..10820485)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10819107..10820485)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44581 Neighboring gene Nitric oxide synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4987 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitric oxide synthase is not essential for Drosophila development. Yakubovich N, et al. Curr Biol, 2010 Feb 23. PMID 20178753, Free PMC Article
  2. Essential function of nitric oxide synthase in Drosophila. Regulski M, et al. Curr Biol, 2004 Oct 26. PMID 15498477
  3. Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling. Rabinovich D, et al. Cell, 2016 Jan 14. PMID 26771490, Free PMC Article
  4. Viruses in Laboratory Drosophila and Their Impact on Host Gene Expression. Kuyateh O, et al. Viruses, 2023 Aug 31. PMID 37766256, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6508-PA
NP_609457.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10819107..10820485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135613.2 → NP_609457.1  uncharacterized protein Dmel_CG6508 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKP7
    Related
    FBpp0079728
    Conserved Domains (2) summary
    pfam00026
    Location:73 → 387
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:68 → 386
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKP7 Q9VKP7

Gene LinkOut

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