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CG6724 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34488, updated on 9-Dec-2024

Summary

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Official Symbol
CG6724provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032298
Locus tag
Dmel_CG6724
See related
AllianceGenome:FB:FBgn0032298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6724
Summary
Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytosol and plasma membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult neuromere; larval muscle cell; and mesoderm. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG6724 in Genome Data Viewer
Location:
32A5-32A5; 2-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10768234..10769952, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10768234..10769952, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44582

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
  2. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
  3. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952
  4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PeBoW complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6724-PA
CG6724-PB
ribosome biogenesis protein WDR12 homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10768234..10769952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273434.1 → NP_001260363.1  uncharacterized protein Dmel_CG6724, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB96
    Conserved Domains (4) summary
    COG2319
    Location:105 → 409
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:105 → 406
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:10 → 75
    NLE; NLE (NUC135) domain
    sd00039
    Location:198 → 248
    7WD40; WD40 repeat [structural motif]

  2. NM_135608.3 → NP_609452.1  uncharacterized protein Dmel_CG6724, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKQ3
    Related
    FBpp0079780
    Conserved Domains (4) summary
    COG2319
    Location:105 → 411
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:105 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:10 → 75
    NLE; NLE (NUC135) domain
    sd00039
    Location:198 → 250
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB96 M9PB96
Q9VKQ3.1 Q9VKQ3

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